Association between biomarkers of oxidative stress, trace elements, and cell proliferation index in patients with benign and malignant breast diseases

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Kanchan KarkiHari D Khanna

Abstract

To understand the association between biomarkers of oxidative stress, antioxidants, trace elements, and cell proliferation index in relation to the disease progression in the pathophysiology of breast diseases. Concentrations of markers of oxidative stress, antioxidants, trace elements, and cell proliferation index were evaluated in the patients with benign breast diseases, malignant breast diseases, and healthy volunteers as controls. Multinomial logistic regression analysis was used to identify the contribution of the selected indexes using odds ratio and associated confidence interval. The level of markers of oxidative stress (malondialdehyde [MDA]) and cell proliferation index were found to be significantly higher with significantly depleted levels of antioxidants and trace elements in breast cancer patients compared with control subjects as well as benign breast disease patients. A similar pattern of changes were observed between benign and control subjects. An inadequate amount of antioxidant enzymes and trace elements may be an important contributing factor associated with oxidative stress leading to elevated levels of MDA and cell proliferation index in relation to disease progression and clinical stage in the pathophys...Continue Reading

Citations

Dec 5, 2017·Biological Trace Element Research·Priscyla Maria Vieira MendesDilina do Nascimento Marreiro
Mar 8, 2019·Journal of Attention Disorders·Christine H WangAndrea Chronis-Tuscano
Sep 9, 2019·Pathology Oncology Research : POR·Archana A GuptaSupriya Kheur
Jan 15, 2021·Biological Trace Element Research·Daila Leite Chaves BezerraDilina do Nascimento Marreiro

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