Association between bleeding tendency and health-related quality of life in carriers of moderate and severe haemophilia

Haemophilia : the Official Journal of the World Federation of Hemophilia
A OlssonF Baghaei

Abstract

Carriers of severe and moderate haemophilia A and B are expected to have approximately 50% of the normal level of factors VIII and IX. However, due to X chromosome inactivation in early embryonic life, factor levels can vary considerably. This can lead to increased bleeding tendency, which may in turn impact on health-related quality of life (HRQOL). The aim of this study was to assess HRQOL in carriers of severe and moderate haemophilia with and without increased bleeding tendency. One hundred and twenty-four adult carriers and 90 controls were recruited. Bleeding tendency was evaluated using a structured bleeding assessment tool. HRQOL was measured by the short form 36 (SF-36) questionnaire. The SF-36 scores were compared with Swedish normative age-matched data and reported as Z scores. There was no significant difference between the whole groups of carriers and controls in the Z scores of the eight SF-36 domains. The mental component summary (MCS) was lower in carriers, compared with controls (P = 0.048). The subgroup of carriers with an increased bleeding tendency had significantly lower Z scores compared to controls regarding the General Health (P = 0.008), the Social Functioning (P = 0.040) and the Mental Health (P = 0.04...Continue Reading

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Citations

Aug 15, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Mehdi OsooliJan Astermark
Aug 26, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Alice NauBrigitte Pan-Petesch
May 27, 2017·Journal of Genetic Counseling·Charlotte von der LippeKari Nyheim Solbrække
Sep 28, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·J E YoungP D James
Dec 23, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Ana Torres-Ortuño
Oct 5, 2019·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·R WinikoffK S Robinson
Jun 26, 2021·Nature Reviews. Disease Primers·Erik BerntorpVictor Blanchette
Jul 31, 2021·Journal of Thrombosis and Haemostasis : JTH·Karin P M van GalenRobert F Sidonio
Aug 4, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Karin van GalenUNKNOWN European Haemophilia Consortium (EHC) and the European Association for Haemophilia and Allied Disorders (EAHAD)
Aug 26, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maria E Carter-Febres, Ming Y Lim

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