Association between blood glucose levels and high-sensitivity cardiac troponin T in an overt cardiovascular disease-free community-based study

Diabetes Research and Clinical Practice
Jin ZhengHongmei Wu

Abstract

To investigate the relationship between blood glucose levels and high-sensitivity cardiac troponin T (hs-cTnT) in an overt cardiovascular disease-free community-based study. Cardiac troponin T levels were measured using a highly sensitive assay in 1365 individuals, aged 45 years or older, without overt cardiovascular disease in a community-based, cross-sectional study, in Beijing, China. All participants underwent anthropometric measurements, biochemical analysis and an oral glucose tolerance test. Both the prevalence of detectable hs-cTnT (≥3.0 pg/mL) and elevated hs-cTnT (≥13.3 pg/mL) were significantly higher in patients with diabetes mellitus (DM) than in patients with normal glucose tolerance (NGT), and those with impaired glucose regulation (IGR). After adjustment for multiple factors, the prevalence of detectable hs-cTnT (adjusted OR=1.22) and elevated hs-cTnT (adjusted OR=1.29) in the DM group were still significantly higher than in the NGT group. hs-cTnT was related to multiple risk factors for cardiovascular events, and fasting blood glucose level was an independent predictor of hs-cTnT. hs-cTnT showed a varied distribution in a community-based population with different blood glucose levels. Both the prevalence of det...Continue Reading

References

Aug 23, 2000·The Journal of Clinical Investigation·B B Kahn, J S Flier
Apr 19, 2006·Circulation·Thomas W WallaceJames A de Lemos
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Jan 11, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·LuXia ZhangHaiYan Wang
Dec 26, 2008·BMJ : British Medical Journal·Dan Atar
Aug 28, 2009·The New England Journal of Medicine·Tobias ReichlinChristian Mueller
Aug 28, 2009·The New England Journal of Medicine·Till KellerStefan Blankenberg
Nov 27, 2009·The New England Journal of Medicine·Torbjørn OmlandUNKNOWN Prevention of Events with Angiotensin Converting Enzyme Inhibition (PEACE) Trial Investigators
Nov 17, 2010·JAMA : the Journal of the American Medical Association·Christopher R deFilippiStephen L Seliger
Dec 9, 2010·JAMA : the Journal of the American Medical Association·James A de LemosDarren K McGuire

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Citations

Jan 30, 2016·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Takashi Hitsumoto
Mar 4, 2014·Journal of the American College of Cardiology·Lieke J J KlinkenbergSteven J R Meex
Aug 26, 2014·Circulation·Elizabeth SelvinJosef Coresh
May 11, 2013·Stroke; a Journal of Cerebral Circulation·Razvan T DaduChristie M Ballantyne

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