Association between Bone Mineral Density of Femoral Neck and Geriatric Nutritional Risk Index in Rheumatoid Arthritis Patients Treated with Biological Disease-Modifying Anti-Rheumatic Drugs

Nutrients
Hiroto TokumotoTakao Setoguchi

Abstract

Treatment of rheumatoid arthritis (RA) with biological disease-modifying anti-rheumatic drugs (bDMARDs) induces rapid remission. However, osteoporosis and its management remains a problem. The Geriatric Nutritional Risk Index (GNRI) evaluates the risk of malnutrition-related complications in elderly patients and has been shown to be a significant predictor of many diseases. We evaluated the correlation between GNRI and RA activity. In addition, risk factors for femoral neck bone loss were evaluated in RA patients treated with bDMARDs. We retrospectively examined the medical records of 146 patients with RA, collecting and recording the patients' demographic and clinical characteristics. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Inverse correlations were observed between GNRI and disease duration, disease activity score-28 joint count serum C-reactive protein (CRP), simple disease activity index, modified health assessment questionnaire score and CRP. GNRI showed correlation with femoral neck BMD and femoral neck BMD ≤ 70% of young adult men (YAM). Multiple regression analysis showed that female sex, increased age and lower GNRI were risk factors for lower BMD of the femoral neck. Multivariate b...Continue Reading

References

Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A KanisN Khaltaev
Jul 10, 1998·The Proceedings of the Nutrition Society·R H Martin
Jan 30, 1999·The American Journal of Clinical Nutrition·R G MungerB C Chiu
Jul 14, 2001·The American Journal of Clinical Nutrition·G Akner, T Cederholm
Nov 15, 2001·Joint, Bone, Spine : Revue Du Rhumatisme·C Gómez-VaqueroD Roig-Escofet
Mar 29, 2003·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K L RennieS A Jebb
Mar 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heidi J WengreenNancy E Sassano
Mar 31, 2005·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickAnne E de Papp
Jun 15, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Bhumika ShahClarie B Hollenbeck
Jul 11, 2006·The American Journal of Clinical Nutrition·Heike A Bischoff-FerrariBess Dawson-Hughes
Nov 26, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·René Rizzoli
Jul 15, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Cheuk-Chun SzetoPhilip Kam-Tao Li
May 6, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D MisraM T Hannan
Oct 5, 2010·Nutrition Reviews·Patrícia de Souza Genaro, Lígia Araújo Martini
Mar 2, 2011·Clinical Rheumatology·Annelies Boonen, Johan L Severens
Dec 6, 2011·Best Practice & Research. Clinical Rheumatology·Nicola J Gullick, David L Scott
Jan 17, 2013·Therapeutic Advances in Endocrinology and Metabolism·Ifigenia Kostoglou-AthanassiouChristodoulos Antoniadis
Feb 5, 2013·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Seok Hui KangJun Young Do
Apr 5, 2013·Journal of Bone and Mineral Metabolism·Satoshi SoenUNKNOWN Japanese Society for Bone and Mineral Research and Japan Osteoporosis Society Joint Review Committee for the Revision of the
Dec 9, 2014·Women's Health·René RizzoliConnie Weaver
Jan 31, 2015·Current Pharmaceutical Design·Andrea CorsonelloRaffaele Antonelli Incalzi
Jun 16, 2016·Geriatrics & Gerontology International·Toshiki KawamiyaToyoaki Murohara
Apr 26, 2017·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·L SargentoR Palma Dos Reis
Jul 5, 2017·Irish Journal of Medical Science·J M G CurneenE Laird

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

BellCurve Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
Zeljka Crncevic OrlicDragica Bobinac
© 2022 Meta ULC. All rights reserved