Association Between Brain-Derived Neurotrophic Factor Genotype and Upper Extremity Motor Outcome After Stroke

Stroke; a Journal of Cerebral Circulation
Won Hyuk ChangYun-Hee Kim

Abstract

The identification of intrinsic factors for predicting upper extremity motor outcome could aid the design of individualized treatment plans in stroke rehabilitation. The aim of this study was to identify prognostic factors, including intrinsic genetic factors, for upper extremity motor outcome in patients with subacute stroke. A total of 97 patients with subacute stroke were enrolled. Upper limb motor impairment was scored according to the upper limb of Fugl-Meyer assessment score at 3 months after stroke. The prediction of upper extremity motor outcome at 3 months was modeled using various factors that could potentially influence this impairment, including patient characteristics, baseline upper extremity motor impairment, functional and structural integrity of the corticospinal tract, and brain-derived neurotrophic factor genotype. Multivariate ordinal logistic regression models were used to identify the significance of each factor. The independent predictors of motor outcome at 3 months were baseline upper extremity motor impairment, age, stroke type, and corticospinal tract functional integrity in all stroke patients. However, in the group with severe motor impairment at baseline (upper limb score of Fugl-Meyer assessment <...Continue Reading

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Citations

Feb 27, 2018·Topics in Stroke Rehabilitation·Margaret A FrenchDarcy S Reisman
Apr 20, 2018·Stroke; a Journal of Cerebral Circulation·Julie BernhardtMichael Tymianski
Aug 11, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Hyun Mi OhSun Im
Jul 31, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nikhil MathPankaj Sharma
Jul 17, 2021·Journal of Neurologic Physical Therapy : JNPT·Bokkyu KimCarolee J Winstein

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