Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline

JAMA Neurology
Lei YuDavid A Bennett

Abstract

Alteration of ex vivo magnetic resonance imaging transverse relaxation is associated with late-life cognitive decline even after controlling for common neuropathologic conditions. However, the underlying neurobiology of this association is unknown. To investigate the association between brain gene expression, DNA methylation, and alteration of magnetic resonance imaging transverse relaxation in late-life cognitive decline. Data came from 2 community-based longitudinal cohort studies of aging and dementia, the Religious Orders Study, which began in 1993, and the Rush Memory and Aging Project, which began in 1997. All participants agreed to undergo annual clinical evaluations and to donate their brains after death. By October 24, 2016, a total of 1358 individuals had died and had brain autopsies that were approved by board-certified neuropathologists. Of those, 552 had undergone ex vivo imaging. The gene expression analysis was limited to 174 individuals with both imaging and brain RNA sequencing data. The DNA methylation analysis was limited to 225 individuals with both imaging and brain methylation data. Maps of ex vivo magnetic resonance imaging transverse relaxation were generated using fast spin echo imaging. The target was ...Continue Reading

Citations

Jun 6, 2018·Journal of Alzheimer's Disease : JAD·David A BennettJulie A Schneider
Jun 24, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Richard ShervaRobert C Green
Dec 29, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Magdalena MroczekWadid Sirry
Jan 7, 2021·Environmental Science and Pollution Research International·Vahid Kazemi MoghadamMohammad Sarmadi
Mar 27, 2021·Frontiers in Oncology·Kaili ChangXueguang Liu
Jun 26, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Jan Klohs, Ann M Hirt

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