Association between brain indole levels and severity of posthypoxic myoclonus in rats

Pharmacology, Biochemistry, and Behavior
R R MatsumotoDaniel D Truong

Abstract

We have previously reported the presence of posthypoxic, audiogenic myoclonus in rats after cardiac arrest and the ability of the 5-HT precursor, 5-HTP, to attenuate these muscle jerks. In addition, we have recently shown that 5-HT2 and 5-HT3 agonists can reduce the severity of myoclonus in these animals, suggesting a deficiency in serotonergic neurotransmission. In the present study, the levels of 5-HTP, 5-HT, and 5-HIAA were measured in seven regions of the brain in myoclonic and normal rats to identify the areas of the brain in which a serotonergic dysfunction resides. Similar to previous studies, we observed pronounced posthypoxic, audiogenic myoclonus 3 and 14 days after resuscitation from cardiac arrest, with a resolution of the abnormal movements by 45 days postarrest. HPLC measurements revealed significant changes in indole levels in the following areas of the brain: cortical 5-HIAA, striatal 5-HT, striatal 5-HIAA, hippocampal 5-HT, mesencephalic 5-HIAA, myelencephalic 5-HT, myelencephalic 5-HIAA, cerebellar 5-HTP, and cerebellar 5-HT. The changes in striatal 5-HT, cortical 5-HIAA, and mesencephalic 5-HIAA appear most relevant to the pathophysiology of posthypoxic myoclonus because regression analyses showed significant...Continue Reading

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Citations

Sep 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·R R MatsumotoD D Truong
Feb 22, 1996·European Journal of Pharmacology·A G KanthasamyD D Truong
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·S P JawD D Truong
Dec 1, 1995·Pharmacology, Biochemistry, and Behavior·S P JawD D Truong
Apr 6, 2001·Clinical Neuropharmacology·K KompolitiR Raman
Aug 28, 2007·Parkinsonism & Related Disorders·Kwok-Keung TaiDaniel D Truong
Jan 31, 2006·Neurologic Clinics·Arun Venkatesan, Steven Frucht

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