Association between Bsm1 Polymorphism in Vitamin D Receptor Gene and Diabetic Retinopathy of Type 2 Diabetes in Korean Population

Endocrinology and Metabolism
Yong Joo HongHyun Jeong Jeon

Abstract

Type 2 diabetes is one of the most common diseases with devastating complications. However, genetic susceptibility of diabetic complications has not been clarified. The vitamin D endocrine system is related with calcification and lipolysis, insulin secretion, and may be associated with many complicated disease including diabetes and cardiovascular disease. Recent studies reported that single nucleotide polymorphisms of vitamin D receptor (VDR) gene were associated with diabetic complications. In present study, we evaluated the association of BsmI polymorphism of VDR with diabetic complications in Korean diabetes patients. Total of 537 type 2 diabetic subjects from the Endocrinology Clinic of Chungbuk National University Hospital were investigated. Polymerase chain reaction-restriction fragment length polymorphism was used to test the genotype and allele frequency of BsmI (rs1544410; BB, Bb, bb) polymorphisms. Mean age was 62.44±10.64 years and mean disease duration was 13.65±7.39 years. Patients with B allele (BB or Bb) was significantly associated with lower risk of diabetic retinopathy (severe non-proliferative diabetic retinopathy or proliferative retinopathy; 7.4%, 5/68) compared with patients without B allele (bb; 17.3%, 8...Continue Reading

References

May 1, 1992·The Journal of Clinical Investigation·B B Kahn
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M P MarcoE Fernández
Nov 30, 2002·European Journal of Endocrinology·Bálazs GyörffyAndrás Szabó

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Citations

Oct 13, 2016·Molecular Biology Reports·Petra PriščákováVanda Repiská
Jan 8, 2017·Reviews in Endocrine & Metabolic Disorders·M GrammatikiKalliopi Kotsa
Apr 24, 2018·Acta Ophthalmologica·Suzanne BroadgateVictor Chong
Sep 27, 2018·Hormones : International Journal of Endocrinology and Metabolism·Maria GrammatikiKalliopi Kotsa
Feb 20, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Sang Won NamDong-Hwa Lee
Apr 18, 2021·The British Journal of Oral & Maxillofacial Surgery·S YildizY Balel

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SPSS

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