Association between bullous pemphigoid and hypovitaminosis D in older inpatients: Results from a case-control study

European Journal of Internal Medicine
M E SarreO Beauchet

Abstract

To compare serum vitamin D status in older inpatients with bullous pemphigoid (BP) and matched inpatients without BP, and to examine whether hypovitaminosis D, a high comorbidity burden or their combination were associated with BP. This prospective case-control study was performed from November 2012 to February 2014. A total of 90 consecutive older inpatients (31 consecutive inpatients with a de novo diagnosis of active BP, and 59 matched controls without BP) were recruited in the Department of Dermatology of Angers University Hospital, France. Hypovitaminosis D was defined as serum 25-hydroxyvitamin D (25OHD) concentration<50nmol/L. Age, gender, functional level, sun exposure, season, comorbidity burden and cognitive performance were used as covariates. There was no significant difference between older inpatients with and without BP. Fully adjusted logistic regression showed a significant association between BP and hypovitaminosis D (odds ratio [OR]=3.7, P=0.046). The analysis of interaction between hypovitaminosis D and comorbidity burden showed that only the association of both was significantly associated with PB (OR=3.1, P=0.042). BP was significantly associated with hypovitaminosis D solely in patients with a high comorbi...Continue Reading

References

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Citations

Nov 2, 2017·European Journal of Nutrition·Yannis ManiosKevin D Cashman
Jul 18, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·K KridinK T Amber
Jun 19, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Giovanni DamianiMichael D Linder
Mar 4, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M KangD F Murrell
Aug 18, 2020·The Journal of Dermatological Treatment·Miao YangQianjin Lu

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