Association between bullous pemphigoid and psoriasis: Systematic review and meta-analysis of case-control studies

The Australasian Journal of Dermatology
Kevin PhanDedee F Murrell

Abstract

Several case reports and cohort studies have recently investigated the potential association between bullous pemphigoid (BP) and psoriasis. It has been speculated that chronic inflammation in the dermo-epidermal junction can trigger exposure to antigens to autoreactive T cells, resulting in autoimmune blistering disease. However, the association described has been inconsistently reported amongst studies. We performed a systematic review and meta-analysis to investigation this potential association. We identified four case-control studies for inclusion in the present meta-analysis, with a total of 4035 bullous pemphigoid cases and 19 215 control cases. There was a significantly higher prevalence of psoriasis in BP compared to controls (2.6% vs 1.1%, OR 2.5, 95% CI 1.4-4.6). Subgroup analysis showed that this association remained significant in both males (3.0% vs 1.3%, OR 2.4, 95% CI 1.6-3.6) as well as females (1.9% vs 0.7%, OR 2.9, 95% CI 1.4-5.9). A significantly higher proportion of cases were reported in males (3.0% vs 1.9%, OR 1.75, 95% CI 1.1-2.7). This pooled analysis of existing case-control studies to date demonstrates a significant association between BP and psoriasis. We also showed that in contrast with the majority...Continue Reading

References

Nov 1, 1976·The British Journal of Dermatology·J R Person, R S Rogers
Jan 1, 1992·The British Journal of Dermatology·B S Baker, L Fry
Sep 1, 1985·The British Journal of Dermatology·C E Grattan
Dec 1, 1972·Archives of Dermatology·D L Cram, K Fukuyama
Feb 12, 1998·The British Journal of Dermatology·Y EndoT Hashimoto
Dec 11, 2002·Clinical and Experimental Dermatology·S D MorrisJ A McGrath
Sep 12, 2006·International Journal of Dermatology·Maria A BarnadasAugostín Alomar
Nov 2, 2006·International Journal of Dermatology·Agnes Wilczek, Michael Sticherling
Sep 8, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Nadège CordelUNKNOWN French Study Group of Bullous Diseases
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Oct 15, 2010·The Journal of Investigative Dermatology·Sylvie Bastuji-GarinUNKNOWN French Study Group for Bullous Diseases
Apr 27, 2011·The British Journal of Dermatology·Y J ChenH N Liu
Jul 18, 2017·Journal of the American Academy of Dermatology·Khalaf Kridin, Reuven Bergman

❮ Previous
Next ❯

Citations

Jul 6, 2019·Frontiers in Immunology·Kaisa TasanenWataru Nishie
Sep 30, 2020·International Journal of Molecular Sciences·Yu Ri WooJung Eun Kim
Oct 25, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·S StänderK Kridin
Oct 12, 2021·The Journal of Dermatology·Lingyi LuBingjiang Lin
Dec 14, 2021·Frontiers in Genetics·Jing GaoChangbing Shen
Jan 25, 2022·Journal of the European Academy of Dermatology and Venereology : JEADV·W-K Hung, C-C Chi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Journal of the American Academy of Dermatology
Khalaf Kridin, Reuven Bergman
Journal of the American Academy of Dermatology
G TaylorK Welch
Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia
M RotoliL Rusciani
Anais Brasileiros De Dermatologia
Vera Barreto TeixeiraAmérico Figueiredo
© 2022 Meta ULC. All rights reserved