Association between cadmium and androgen receptor protein expression differs in prostate tumors of African American and European American men

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Christine Neslund-DudasBharati Mitra

Abstract

Cadmium is a known carcinogen that has been implicated in prostate cancer, but how it affects prostate carcinogenesis in humans remains unclear. Evidence from basic science suggests that cadmium can bind to the androgen receptor causing endocrine disruption. The androgen receptor is required for normal prostate development and is the key driver of prostate cancer progression. In this study, we examined the association between cadmium content and androgen receptor protein expression in prostate cancer tissue of African American (N = 22) and European American (N = 30) men. Although neither overall tumor cadmium content (log transformed) nor androgen receptor protein expression level differed by race, we observed a race-cadmium interaction with regard to androgen receptor expression (P = 0.003) even after accounting for age at prostatectomy, smoking history, and Gleason score. African American men had a significant positive correlation between tumor tissue cadmium content and androgen receptor expression (Pearson correlation = 0.52, P = 0.013), while European Americans showed a non-significant negative correlation between the two (Pearson correlation = -0.19, P = 0.31). These results were unchanged after further accounting for tis...Continue Reading

Citations

Sep 15, 2019·Environmental Research·Alina-Andreea ZimtaIoana Berindan-Neagoe
Jan 28, 2021·Journal of Endocrinological Investigation·V M BimonteS Migliaccio
Mar 19, 2021·Environmental Analysis, Health and Toxicology·Lalit ChandravanshiSudhir Kumar

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