Association between calcifying nanoparticles and placental calcification

International Journal of Nanomedicine
Ya-nan GuoXuecheng Shen


The purpose of this study was to examine the possible contribution of calcifying nanoparticles to the pathogenesis of placental calcification. Calcified placental tissues and distal tissue samples were collected from 36 confirmed placental calcification cases. In addition, 20 normal placental tissue samples were obtained as a control group. All the tissue samples were cultured using special nanobacterial culture methods. The cultured calcifying nanoparticles were examined by transmission electron microscopy (TEM), and their growth was monitored by optical density (OD) at a wavelength of 650 nm. 16S rRNA gene expression of the cultured calcifying nanoparticles was also isolated and sequenced. Novel calcifying nanoparticles wrapped with electron-dense shells between 50 nm to 500 nm in diameter were observed in the extracellular matrix of calcified placental tissues. They were detected in placental villi and hydroxyapatite crystals, and contained "nucleic acid-like materials". After isolation and four weeks of culture, 28 of 36 calcified placental tissue samples showed white granular precipitates attached to the bottom of the culture tubes. OD(650) measurements indicated that the precipitates from the calcified placental tissues w...Continue Reading


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Related Concepts

Pathogenic Aspects
Crystal - Body Material
Placenta Disorders
Extracellular Matrix
Nucleic Acid Sequencing
Calcifying Nanoparticles
Chorionic Villi
Particle Size

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