Association between calcium channel blockers and gingival hyperplasia

Journal of Clinical Periodontology
Gaganpreet KaurMiriam C J M Sturkenboom

Abstract

To study the effect of the dose and type of calcium channel blockers (CCBs) on the risk of gingival hyperplasia and to quantify this association. The study was conducted within the Integrated Primary Care Information Project in The Netherlands. A nested case-control study was designed within a cohort of all patients who were new users of either CCBs or drugs interacting with the renin-angiotensin system (RAS). Cases were all individuals with a validated diagnosis of gingival hyperplasia. Controls were matched on age, gender and index date. Within the study population, 103 cases of gingival hyperplasia were identified and matched to 7677 controls. The risk of gingival hyperplasia was higher in current users of CCBs [adjusted odds ratio (OR(adj)) 2.2, 95% confidence intervals (95% CI): 1.4-3.4], especially in dihydropyridines (OR(adj) 2.1, 95% CI: 1.3-3.5) and benzothiazepine derivatives (OR(adj) 2.9, 95% CI: 1.3-6.5) than in RAS drug users. The risk increased in patients using more than the recommended daily dose (OR(adj) 3.0, 95% CI: 1.6-5.5) and when the duration of current use was <1 month (OR(adj) 5.2, 95% CI: 2.1-12.6). This study shows that the risk of gingival hyperplasia is twofold higher in current users of CCBs than in...Continue Reading

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Citations

Aug 25, 2015·Journal of Cell Communication and Signaling·Shawna S KimDouglas W Hamilton
Sep 29, 2012·Dental Clinics of North America·Jonathan Hogan, Jai Radhakrishnan
May 17, 2011·Disease-a-month : DM·Nuha Nakib, Seema S Ashrafi
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Sep 23, 2014·Jundishapur Journal of Natural Pharmaceutical Products·Ali Asghar HemmatiHossein Mohammad Asgari
May 11, 2021·World Journal of Cardiology·Lucija BajkovecIvan Alajbeg

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