Abstract
Studies have suggested that the Calpain-10 gene polymorphisms may play a role in polycystic ovary syndrome (PCOS) susceptibility. Thus, the aim of the present study was to evaluate the possible association between three single nucleotide polymorphisms (SNPs) in the calpain-10 gene (UCSNPs -43, -19, and -63) and polycystic ovary syndrome (PCOS) in Chilean women. Fifty women with PCOS (28.8+/-8.2 y) and 70 healthy women (28.6+/-8.6 y) were included in this study. Serum lipids, hormonal status, fasting glucose, oral glucose tolerance test (OGTT), insulin, HOMAIR, and uric acid levels were determined by conventional methods. The calpain-10 gene variants were detected by PCR and PCR-RFLP, respectively. The presence of uncommon allele (A) for the UCSNP-43 was associated with increased risk of PCOS (odds ratio=1.93, 95% CI: 1.11-3.34). The UCSNP-63 (OR=1.11, 95% CI: 0.59-2.11) and UCSNP-19 (OR=0.93, 95% CI: 0.55-1.57) were not associated to PCOS. However, the PCOS women carrying the CC genotype for UCSNP-63 exhibited higher values of total cholesterol and LDL-C (P<0.05). Similarly, control women carrying the CC genotype showed higher serum levels of triglycerides, HDL-C and uric acid (P<0.05). Our data suggest the contribution of CAPN...Continue Reading
References
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Mar 1, 1996·Clinical Endocrinology·S RobinsonS Franks
Sep 1, 1996·Human Reproduction·D MeirowE M Berry
Nov 1, 1996·Clinical Endocrinology·M SampsonH S Jacobs
Oct 4, 2000·Nature Genetics·Y HorikawaG I Bell
Feb 24, 2001·Human Reproduction Update·P G Crosignani, A E Nicolosi
Mar 2, 2002·Fertility and Sterility·Héctor F Escobar-MorrealeJosé L San Millán
Mar 14, 2002·Diabetes Research and Clinical Practice·Makoto DaimonTakeo Kato
Apr 30, 2002·Diabetes·Paul G CassellGraham A Hitman
Jun 7, 2002·The Journal of Clinical Endocrinology and Metabolism·Lema HaddadMark I McCarthy
Jul 30, 2002·Diabetes·Marju Orho-MelanderLeif Groop
Sep 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yukio ShimaHidehiko Ohta
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Alejandro GonzalezAgustín Ruiz
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Jan 20, 2004·American Journal of Human Genetics·Yiqing SongSimin Liu
Mar 11, 2004·Journal of Endocrinological Investigation·E Carmina
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Emma CarlssonMartin Ridderstråle
Sep 24, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·Paula Amato, Joe Leigh Simpson
Jul 5, 2005·Human Reproduction Update·Evanthia Diamanti-Kandarakis, Christina Piperi
Nov 30, 2005·Atherosclerosis·Andrea J CussonsGerald F Watts
Mar 21, 2006·Diabetes Research and Clinical Practice·Eun Seok KangHyun Chul Lee
May 25, 2006·Journal of Human Genetics·Eun Seok KangHyun Chul Lee
Nov 16, 2006·American Journal of Physiology. Endocrinology and Metabolism·Caren VollmertUNKNOWN KORA group
Jan 27, 2007·Current Diabetes Reports·Andrea J CussonsGerald F Watts
Apr 25, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Denusa WiltgenPoli Mara Spritzer
Aug 28, 2007·Lancet·Robert J NormanTheresa E Hickey
Sep 15, 2007·Human Molecular Genetics·Yiqing SongSimin Liu
Dec 20, 2007·Ultrasound Quarterly·Michele A Brown, R Jeffrey Chang
Apr 17, 2008·The Journal of Obstetrics and Gynaecology Research·Sudhindra M Bhattacharya
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Djuro MacutSvetozar Damjanović
May 20, 2008·Diabetes & Metabolism·C KifagiH Ayadi
Citations
Apr 24, 2009·Journal of Assisted Reproduction and Genetics·Tugba UnsalAdnan Menevse
Jun 25, 2013·Journal of Assisted Reproduction and Genetics·Bhaskar Venkata Kameswara Subrahmanya LakkakulaUsha Rani Godla
Oct 26, 2013·Gene·A Ben-SalemT Mahjoub
Apr 29, 2014·Reproductive Biomedicine Online·Izhar Ben-Shlomo, Johnny S Younis
Sep 3, 2013·Gene·Wenjing ShenMin Song
Feb 11, 2014·Archives of Medical Research·Pablo PánicoPatricia Ostrosky-Wegman
Oct 20, 2012·Molecular and Cellular Endocrinology·Gülüm Kosova, Margrit Urbanek
Sep 13, 2011·Clinical Endocrinology·Miaoling HuangQing Chen
May 20, 2015·Cirugia y cirujanos·Silvia Esperanza Flores-MartínezJosé Sánchez-Corona
Feb 18, 2010·Human Reproduction Update·Lisa J MoranRobert J Norman
Jul 6, 2014·Molecular Biology Reports·Assila Ben SalemTouhami Mahjoub
Mar 29, 2018·Human Reproduction Update·N S KakolyL J Moran
Nov 6, 2021·Frontiers in Endocrinology·Lucas Bandeira MarchesanPoli Mara Spritzer