Association between cardiac autonomic neuropathy and hypertension and its potential influence on diabetic complications

Diabetic Medicine : a Journal of the British Diabetic Association
F AyadP Valensi

Abstract

To examine the association between cardiac autonomic neuropathy and hypertension and the role of this association in diabetic complications. We included 310 patients, 138 with Type 1 and 172 with Type 2 diabetes, 62 of them with hypertension. Cardiac autonomic neuropathy was assessed by analysing heart rate variations during three standard tests (deep breathing, lying to standing and Valsalva) and looking for postural hypotension. Cardiac autonomic neuropathy was present in 123 patients and 39 also had hypertension. The prevalence of a cardiac autonomic neuropathy/hypertension association was higher in Type 2 patients (P < 0.002). The prevalence of hypertension increased with the severity of cardiac autonomic neuropathy. In multiple logistic regression analysis, cardiac autonomic neuropathy was an independent risk factor for hypertension [odds ratio 2.86 (1.54-5.32); P < 0.001]. Only confirmed or severe cardiac autonomic neuropathy (two or more abnormal function tests, respectively) were independent risk factors for hypertension (P < 0.005 and < 0.0001). Cardiac autonomic neuropathy was found in most of the patients with macrovascular complications, retinopathy or nephropathy, but a large majority of the patients with these com...Continue Reading

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Citations

Oct 30, 2013·Cardiovascular Diabetology·Oliver SchnellAntonio Ceriello
Sep 29, 2015·Journal of Diabetes and Its Complications·Ludovit GasparAndrej Dukat
Jan 6, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·P ValensiUNKNOWN DESIR Study Group
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Feb 19, 2020·Expert Opinion on Pharmacotherapy·Alexandra KatsimardouVasilios G Athyros
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Jun 10, 2011·Current Opinion in Cardiology

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