Association between cardiovascular autonomic neuropathy and left ventricular hypertrophy in diabetic haemodialysis patients

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Masato NishimuraToshihiko Ono

Abstract

Patients with diabetic nephropathy are likely to have neurological complications including cardiovascular autonomic dysfunction, which is related to increased risk of mortality. We investigated whether cardiovascular autonomic neuropathy is associated with left ventricular hypertrophy (LVH) in diabetic haemodialysis patients. Holter electrocardiography was carried out for 24 h with time and frequency domain analyses of heart rate variability in 154 diabetic (age 62+/-11 years) and 63 non-diabetic haemodialysis patients (62+/-10 years). The left ventricular mass index (LVMI) was determined by echocardiography. We used the percentage of differences exceeding 50 ms between adjacent normal RR intervals (pNN50) in time domain analysis and the power in the high-frequency range (HF: 0.15-0.40 Hz) in frequency domain analysis as indicators of parasympathetic activity. The mean LVMI was greater in diabetic than in non-diabetic patients (168+/-63 vs 144+/-54 g/m(2), P<0.01). LVMI inversely correlated with pNN50 (r = -0.270, P = 0.0007, n = 154) and HF (r = -0.277, P = 0.0005, n = 154) in diabetic patients, but not in non-diabetic patients. By multiple logistic analysis, LVH was strongly associated with pNN50 (odds ratio 0.088; 0, <2%; 1,...Continue Reading

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Citations

Nov 23, 2006·Current Diabetes Reports·Aaron I Vinik, Tomris Erbas
May 31, 2012·Journal of Cardiovascular Translational Research·Rodica Pop-Busui
Feb 25, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carmine Zoccali
May 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christopher T Chan
Jan 16, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dvora RubingerDan Sapoznikov
Oct 6, 2005·Current Opinion in Nephrology and Hypertension·Lindsay J Chesterton, Christopher W McIntyre
Jul 10, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Christopher T ChanUNKNOWN Frequent Hemodialysis Network Daily Trial Group
Oct 1, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christopher T ChanUNKNOWN Frequent Hemodialysis Network Daily Trial Group
Mar 30, 2013·International Urology and Nephrology·Jing Zhang, Ningning Wang
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Mar 5, 2013·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Hisako FujiiYoshiki Nishizawa
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Apr 3, 2020·Current Vascular Pharmacology·Athanasios RoumeliotisAndreas Pierratos

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