Association between Carotid Intima-Media Thickness and Cognitive Impairment in a Chinese Stroke Population: A Cross-sectional Study

Scientific Reports
Wei YueYong Ji

Abstract

This study aimed to investigate the potential associations between carotid intima-media thickness and cognitive impairment among patients with acute ischemic stroke and to identify the clinical implications. We measured carotid intima-media thickness (IMT) and performed the Mini-Mental State Examination (MMSE) upon the admission of 1,826 acute ischemic stroke patients. The association between IMT and cognitive impairment evaluated by the MMSE was assessed with a multivariate regression analysis. Other clinical variables of interest were also assessed. After adjusting for potential confounders, participants in the highest IMT quartile had a higher likelihood of having cognitive impairments compared with the lowest IMT quartile (odds ratio: 3.01, 95% confidence interval: 2.07-4.37, p < 0.001). Stratified analyses indicated that this positive correlation was similar for the maxIMT and meanIMT of carotid artery measurements. A positive correlation was found between IMT and cognitive impairment in participants with acute ischemic stroke.

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Citations

Oct 24, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A WangY Wang
Jun 21, 2017·Stroke; a Journal of Cerebral Circulation·Hannah GardenerClinton B Wright
Dec 3, 2016·Stroke; a Journal of Cerebral Circulation·Anxin WangYilong Wang
Aug 23, 2019·International Journal of Environmental Research and Public Health·Jinkee ParkHyuntae Park
Sep 6, 2017·Journal of the Neurological Sciences·Xiaoxuan LiYanhong Dong

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