Association between carotid plaque enhancement shown by multidetector CT angiography and histologically validated microvessel density.

European Radiology
L SabaM Piga

Abstract

Carotid plaques analysed by MDCTA can show contrast enhancement. The purpose of this study was to explore the association between carotid plaque enhancement (CPE) and microvessel density. We obtained IRB approval. Twenty-nine consecutive (male, 20; median age, 63) symptomatic patients studied with 16-detector CT were prospectively analysed. Examinations were performed before and after intravenous contrast medium administration, and analysis of plaque enhancement was performed. Patients underwent "en bloc" carotid endarterectomy; histological sections were prepared and the presence of microvessels quantified. Logistic regression analysis as well as ROC curve and area under the curve was calculated. A statistically significant association between the degree of CPE and microvessel density (P = 0.009; rho = 0.553) was observed. The ROC curve analysis confirmed this association with an area under the curve of 0.906, 0.735, 0.644 and 0.546 for CPE of 10 HU, 15 HU, 20 HU and 25 HU respectively. There was a statistically significant difference between the CPE and the degree of neovascularisation (P = 0.0003). Results of this preliminary study suggest that CPE might be associated with the microvessel density. Histological analysis seems...Continue Reading

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Citations

Jan 2, 2014·Neurosurgical Focus·Elizabeth TongMax Wintermark
Aug 6, 2013·Cardiovascular and Interventional Radiology·Luca SabaMax Wintermark
Dec 24, 2013·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Cyrille NaimGilles Soulez
Oct 9, 2012·AJNR. American Journal of Neuroradiology·L SabaM Piga
Aug 1, 2015·Journal of Neurosurgery·Waleed BrinjikjiGiuseppe Lanzino
Nov 28, 2015·Neuroimaging Clinics of North America·Mahmud Mossa-Basha, Bruce A Wasserman
Oct 24, 2013·Journal of Magnetic Resonance Imaging : JMRI·Luca SabaJasjit S Suri
Jan 13, 2018·AJNR. American Journal of Neuroradiology·L SabaUNKNOWN Vessel Wall Imaging Study Group of the American Society of Neuroradiology
Dec 2, 2017·AJNR. American Journal of Neuroradiology·L SabaG Faa
Jul 28, 2018·Journal of Computer Assisted Tomography·Dylan N WolmanJeremy J Heit
Feb 8, 2020·AJNR. American Journal of Neuroradiology·H Baradaran, A Gupta
Aug 1, 2020·AJNR. American Journal of Neuroradiology·L SabaR Montisci
Feb 6, 2017·Insights Into Imaging·Vasileios RafailidisAfroditi Charitanti-Kouridou

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