Association between Carotid Wall Shear Rate and Arterial Stiffness in Patients with Hypertension and Atherosclerosis of Peripheral Arteries

International Journal of Vascular Medicine
Vadim V GenkelIgor I Shaposhnik

Abstract

To evaluate carotid wall shear rate (WSR) in association with local and regional vascular stiffness in patients with hypertension (HTN) and atherosclerosis of peripheral arteries and to study the pattern of change of WSR in patients with HTN with increasing severity of peripheral artery atherosclerosis. Study involved 133 patients with HTN, 65 men and 48 women, aged in average 57.9±10.8 years. All patients were divided into four groups in accordance with ultrasound morphologic classification of vessel wall. Duplex scanning of carotid and lower limb arteries was performed. Carotid-femoral (cfPWV) and carotid-radial (crPWV) pulse wave velocity (PWV) were measured. Local carotid stiffness was evaluated by carotid ultrasound. WSR of patients with plaques without and with hemodynamic disturbance was 416±128 s-1 and 405±117 s-1, respectively, which was significantly less than the WSR in patients with intact peripheral arteries - 546±112 s-1. Decreased carotid WSR was associated with increased crPVW, cfPWV, Peterson's elastic modulus, decreased distensibility, and distensibility coefficient. In patients with HTN and atherosclerotic lesions of peripheral arteries, it is registered that the carotid WSR decreased with increasing severity...Continue Reading

References

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Citations

Nov 30, 2019·International Angiology : a Journal of the International Union of Angiology·Antonio ValvanoUgo Oliviero
Aug 1, 2019·Current Cardiology Reviews·Vadim V GenkelIgor I Shaposhnik
May 1, 2021·International Journal of Molecular Sciences·Patrizia MarcheseChiara Foglieni

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