Association between cationic liposomes and low molecular weight hyaluronic acid

Langmuir : the ACS Journal of Surfaces and Colloids
Antonio A M GasperiniLeide P Cavalcanti

Abstract

This work presents a study of the association between low molecular weight hyaluronic acid (16 kDa HA) and cationic liposomes composed of egg phosphatidylcholine (EPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). The cationic liposome/HA complexes were evaluated to determine their mesoscopic structure, average size, zeta potential, and morphology as a function of the amount of HA in the system. Small angle X-ray scattering results revealed that neighboring cationic liposomes either stick together after a partial coating of low concentration HA or disperse completely in excess of HA, but they never assemble as multilamellar vesicles. Cryo-transmission electron microscopy images confirm the existence of unilamellar vesicles and large aggregates of unilamellar vesicles for HA fractions up to 80% (w/w). High concentrations of HA (> 20% w/w) proved to be efficient for coating extruded liposomes, leading to particle complexes with sizes in the nanoscale range and a negative zeta potential.

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Citations

Jan 28, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Tiago Albertini BalbinoLucimara Gaziola de La Torre
Apr 15, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuchen FanJames J Moon
Jan 30, 2018·European Biophysics Journal : EBJ·Irene WoodMonica Pickholz
Apr 30, 2021·International Journal of Pharmaceutics·Solmaz Mojarad-JabaliHadi Valizadeh
Jul 3, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Martina HavlíkováFilip Mravec
Jul 25, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Chloé SeyrigNiki Baccile
Jan 14, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Takeshi TeradaPieter R Cullis

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