Association between Cerebral Arterial Stiffness and Large Artery Atherosclerosis in Acute Ischemic Stroke

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Xian FuQingchun Gao

Abstract

Carotid-cerebral pulse wave velocity (ccPWV) reflects the segment (C-M segment) stiffness between common carotid artery and ipsilateral middle cerebral artery. The C-M segment atherosclerosis (CMSA) is regarded as a most frequent cause of anterior circulation ischemic stroke. We therefore, attempted to investigate the relationship between cerebral arterial stiffness and CMSA, and provide reliable data for the early diagnosis of CMSA. Between June 2012 and August 2016, 81 acute ischemic stroke (AIS) patients with 154 C-M segments successfully evaluated with digital subtraction angiography and ccPWV were enrolled into this study. Patient demographics and clinical data were retrieved from our AIS databases. Multivariate analyses showed that ccPWV was independently associated with CMSA (β = 39.6, P = .009) and Systolic blood pressure (β = 7.1, P < .001) in AIS patients. The values of ccPWV had a trend to be higher in the groups with more lesions (F = 45.9, P < .01) and severer stenosis (F = 102.6, P = .000), and was positively correlated with the number of lesions (r = .662, P = .000), and degree of stenosis (r = .858, P = .000) of CMSA. The fractional polynomial plots with 95% CIs also describe the close relationship between ccPWV...Continue Reading

Citations

May 28, 2019·Journal of Atherosclerosis and Thrombosis·Xian FuQingchun Gao
May 2, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Christopher S BalestriniJ Kevin Shoemaker
Aug 15, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xian FuJianping Jia
Apr 27, 2019·Frontiers in Cardiovascular Medicine·Hack-Lyoung Kim, Sang-Hyun Kim

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