Association between changes in fat distribution and biomarkers for breast cancer

Endocrine-related Cancer
Willemijn A M van GemertPetra H Peeters

Abstract

We assessed the associations between changes in total and abdominal fat and changes in biomarkers for breast cancer risk using data of the SHAPE-2 trial. In the SHAPE-2 trial, 243 postmenopausal overweight women were included. The intervention in this trial consisted of 5-6 kg weight loss either by diet only or exercise plus diet. After 16 weeks, we measured serum sex hormones, inflammatory markers, total body fat (measured by DEXA scan) and intra and subcutaneous abdominal fat (measured by MRI). Associations between changes in different body fat depots and biomarkers were analysed by linear regression using the study cohort irrespective of randomisation to make maximal use of the distribution of changes in fat measures. We found that a loss in total body fat was associated with favourable changes in free oestradiol, free testosterone, leptin and sex hormone binding globulin (SHBG). The loss of intra-abdominal fat was associated with a decrease in free testosterone, hsCRP and leptin, and an increase in SHBG. In the multivariable analysis, the best fitted models for the biomarkers free oestradiol, SHBG leptin and adiponectin included only total body fat. For free testosterone, this was subcutaneous abdominal fat, and for hsCRP a...Continue Reading

References

Mar 1, 1991·International Journal of Epidemiology·S A KayeJ D Potter
Jan 1, 1987·The American Journal of Clinical Nutrition·P K Siiteri
Oct 1, 1984·Radiology·W T Dixon
Aug 9, 1997·Lancet·P Björntorp
Jun 27, 1998·Lancet·P Arner
Apr 20, 2001·The Proceedings of the Nutrition Society·R Kaaks, A Lukanova
Apr 18, 2002·Journal of the National Cancer Institute·T KeyUNKNOWN Endogenous Hormones and Breast Cancer Collaborative Group
Jan 24, 2004·Diabetes Research and Clinical Practice·Keun-Gyu ParkIn-Kyu Lee
Aug 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Gloria Lena VegaScott M Grundy
Nov 18, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S A Ritchie, J M C Connell
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Somdat MahabirPhilip R Taylor
Mar 22, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Pierre DesprésPaul Poirier
Mar 25, 2008·Journal of Clinical Epidemiology·Crystal Man Ying LeeMark Woodward
Apr 9, 2008·European Journal of Endocrinology·Laura M RitlandUlrike Genschel
May 30, 2008·Breast Cancer Research and Treatment·Laura BagliettoGraham G Giles
Jul 31, 2008·Journal of Magnetic Resonance Imaging : JMRI·Vincenzo PositanoAmalia Gastaldelli
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Michael D Jensen
Nov 14, 2008·The New England Journal of Medicine·T PischonE Riboli
Aug 19, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evelyn M MonninkhofAlbertine J Schuit
Sep 17, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rob C M van KruijsdijkFrank L J Visseren
Feb 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine M FriedenreichKerry S Courneya
Jan 26, 2011·Nature Reviews. Cardiology·Beatriz Cepeda-ValeryAbel Romero-Corral
Jul 23, 2011·Diabetologia·A T TurerP E Scherer
Jan 14, 2012·Obesity·Stefanie LiedtkeKaren Steindorf
Nov 15, 2012·Nature Reviews. Cardiology·Mohamed HassanMagdi Yacoub
Jan 11, 2013·Physiological Reviews·André Tchernof, Jean-Pierre Després
Mar 29, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Yong-Zhong GuoXiao-Mei Xie
Oct 8, 2013·The Journal of Clinical Endocrinology and Metabolism·D J Handelsman, L Wartofsky
Mar 19, 2014·Journal of the American Geriatrics Society·Alice S RyanAndrew P Goldberg
Apr 17, 2014·International Journal of Epidemiology·Debora MacisSara Gandini
Feb 26, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Willemijn A van GemertEvelyn M Monninkhof
Jul 28, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·W MaL Qi

❮ Previous
Next ❯

Citations

Dec 14, 2017·Breast Cancer Research and Treatment·Jonna K van VulpenKaren Steindorf
Apr 9, 2020·European Journal of Applied Physiology·Paola Gonzalo-EncaboAlberto Pérez-López
Oct 7, 2019·Journal of Hepatology·Giulio MarchesiniHelena Cortez-Pinto
Feb 19, 2021·Molecular and Cellular Biochemistry·Deborah MolehinKevin Pruitt
Apr 18, 2021·Medical Physics·Kiaran P McGeeCaroline Chung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Willemijn A M van GemertEvelyn M Monninkhof
International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
A S RyanD Elahi
© 2022 Meta ULC. All rights reserved