Abstract
Atopic dermatitis (or eczema) is a chronic inflammatory disorder associated with sleep disturbances and quality-of-life impairment. Sleep disturbances have been shown to cause headaches in childhood. However, an association between eczema and headaches is not well established. We sought to determine whether childhood eczema is associated with increased headaches and whether such association is related to fatigue or sleep disturbance. We analyzed data from 401,002 children and adolescents in 19 US population-based cross-sectional studies from the National Survey of Children's Health 2003/2004 and 2007/2008 and the National Health Interview Survey 1997-2013. In multivariate models controlling for age, sex, race/ethnicity, household income, highest level of education in the family, insurance coverage, number of persons in the household, birthplace in the United States, ever history of asthma, hay fever, and food allergy, eczema was found to be associated with headaches in 14 of 19 studies. In a pooled analysis of all 19 studies, children with eczema compared with those without eczema had a significantly higher prevalence (10.7% [95% CI, 10.3% to 11.0%] vs 5.4% [95% CI, 5.3% to 5.5%]) and odds (1.52 [95% CI, 1.45-1.59]) of headache...Continue Reading
References
Mar 1, 1982·Clinical Allergy·R V HeatleyJ Bienenstock
Feb 1, 1995·Scandinavian Journal of Work, Environment & Health·P SusitaivalM Horsmanheimo
Sep 1, 1993·Headache·M J MortimerD C Barker
Feb 17, 1999·The British Journal of Dermatology·U KrämerJ Ring
Sep 29, 2001·Headache·I MunnoV Centonze
Mar 19, 2003·Scandinavian Journal of Immunology·P GazeraniA Kazemnejad
Jul 3, 2003·Pediatrics·Scott W PowersAndrew D Hershey
Nov 17, 2006·The British Journal of Dermatology·P E Beattie, M S Lewis-Jones
Apr 17, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giampaolo RicciMassimo Masi
Aug 7, 2008·Clinical and Experimental Dermatology·K L E HonP C Ng
May 2, 2009·Journal of Child Neurology·Tarannum M LateefKarin B Nelson
Jun 3, 2009·The British Journal of Dermatology·C FlohrUNKNOWN ISAAC Phase Two Study Group
May 29, 2010·Pharmacological Reports : PR·Leszek BoćkowskiKrzysztof Sendrowski
Nov 22, 2011·International Journal of Dermatology·Parker J MaginSusan M Goode
Dec 19, 2012·The Journal of Allergy and Clinical Immunology·Pouya YaghmaieEric L Simpson
Jun 19, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jonathan I Silverberg, Eric L Simpson
Aug 29, 2013·Archives of Dermatological Research·F C BeikertM Augustin
Apr 5, 2014·Journal of Clinical and Diagnostic Research : JCDR·David Rosario, George Pinto
Apr 10, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Nitin Garg, Jonathan I Silverberg
Jun 6, 2014·Headache·Pedro A S Rocha-Filho, Patricia V Santos
Jul 24, 2014·Cephalalgia : an International Journal of Headache·Philip R Holland
Aug 1, 2014·The Journal of Investigative Dermatology·Jonathan I SilverbergPhyllis C Zee
Aug 1, 2014·Cephalalgia : an International Journal of Headache·Nunu LundRigmor Højland Jensen
Aug 22, 2014·Cephalalgia : an International Journal of Headache·Stefan Evers
Nov 25, 2014·Current Pain and Headache Reports·Catherine Diana Stark, Richard James Stark
Dec 6, 2014·Current Neurology and Neuroscience Reports·Jeanetta C RainsTodd A Smitherman
Dec 11, 2014·JAMA Dermatology·Jonathan I Silverberg, Amy S Paller
Jan 13, 2015·Cephalalgia : an International Journal of Headache·M BarloeseR Jensen
Jan 13, 2015·The Journal of Allergy and Clinical Immunology·Jonathan I Silverberg, Philip Greenland
May 2, 2015·Allergy·J Garcia-AymerichJ M Antó
Citations
Apr 20, 2016·The Journal of Allergy and Clinical Immunology·Paulina WawrzyniakMarc E Rothenberg
May 2, 2016·Seminars in Fetal & Neonatal Medicine·Mei WangSharon M Donovan
May 12, 2016·The Journal of Dermatological Treatment·Jonathan I SilverbergGil Yosipovitch
Oct 30, 2016·The British Journal of Dermatology·M A StromJ I Silverberg
Oct 16, 2016·Journal of the American Academy of Dermatology·Alexander EgebergJacob P Thyssen
Mar 21, 2017·Pediatric Dermatology·Rony Shreberk-HassidimAbraham Zlotogorski
Mar 2, 2017·Current Opinion in Neurology·Aynur ÖzgeHayrunnisa Bolay
Sep 2, 2017·Headache·Hsiangkuo Yuan, Stephen D Silberstein
Mar 24, 2018·F1000Research·Jonathan I Silverberg
Dec 21, 2020·BMC Dermatology·Elaine C SiegfriedAbhijit Gadkari
Mar 6, 2021·Journal of the American Academy of Dermatology·Brian T Cheng, Jonathan I Silverberg
May 2, 2021·Pediatric Dermatology·Jaya Manjunath, Jonathan I Silverberg