Association Between Choroidal Thickness and Metabolic Activity on Positron Emission Tomography in Eyes With Choroidal Melanoma

American Journal of Ophthalmology
Ji Hwan LeeChristopher S Lee

Abstract

To investigate the relationship between subfoveal choroidal thickness and metabolic activity in eyes with choroidal melanoma. Retrospective, interventional case series. The medical records of 16 patients with unilateral choroidal melanoma who underwent ruthenium (Ru) 106 brachytherapy with adjuvant transpupillary thermotherapy and who had available pretreatment positron emission tomography-computed tomography (PET-CT) images were retrospectively reviewed. Subfoveal choroidal thickness was measured in tumor eyes and in unaffected fellow eyes using enhanced-depth imaging spectral-domain optical coherence tomography (EDI OCT). Tumor eyes were divided into 2 groups (metabolically active and inactive) based on PET-CT findings and subfoveal choroidal thickness was compared between groups. Additionally, choroidal thickness measurements were compared before and after treatment. Before treatment, mean choroidal thickness was 293.31 ± 46.80 μm in tumor eyes and 242.44 ± 65.37 μm in fellow eyes, a difference that was statistically significant (P = .003). Eyes with metabolically active tumors had a significantly thicker choroid (348.00 ± 17.32 μm) than eyes with metabolically inactive tumors (280.69 ± 42.04 μm, P = .019). In tumor eyes, me...Continue Reading

References

Jan 1, 1992·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E MessmerA Wessing
Mar 1, 1995·Archives of Ophthalmology·J A OosterhuisJ C Bleeker
Oct 1, 1996·Ophthalmology·E MidenaS Piermarocchi
Mar 1, 1997·The British Journal of Ophthalmology·J G Journée-de KorverH Kemme
Mar 25, 1998·American Journal of Ophthalmology·K TakahashiK Shimizu
Oct 29, 1999·Journal of Cancer Research and Clinical Oncology·U GraevenD K Hossfeld
Nov 5, 2003·Ophthalmology·Edoardo MidenaStefano Piermarocchi
Jul 22, 2008·American Journal of Ophthalmology·Richard F SpaideMaria C Pozonni
May 18, 2010·Ophthalmology·Ichiro MarukoRichard F Spaide
Feb 15, 2011·The British Journal of Ophthalmology·Christopher Seungkyu LeeSung Chul Lee
Nov 23, 2011·Retina·Natalia V BajenovaMark W Johnson
Jul 6, 2013·JAMA Ophthalmology·Karun S AroraHenry D Jampel

❮ Previous
Next ❯

Citations

Jan 19, 2016·American Journal of Ophthalmology·Ji Hwan LeeChristopher Seungkyu Lee
Mar 24, 2016·Ocular Immunology and Inflammation·Abdullah KayaTuncay Topal
Dec 29, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jee Hung KimSang Joon Shin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.