Association between CHRNA3 rs1051730 genotype and lung cancer risk in Chinese Han population: a case-control study

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Jing-hua RenTao Zhang

Abstract

Recent population-based genome wide association studies have revealed potential susceptibility loci of lung cancer at the region of chromosome 15q25.1 containing nicotinic acetylcholine receptor genes. The loci increasing lung cancer risk has been widely identified in Caucasians, but whether this association also exists in Asians and whether this association is a direct role or mediated via tobacco smoking indirectly has not been fully established. We conducted a case-control study comprising of 210 histologically confirmed lung cancer cases and 200 healthy controls to examine rs1051730 genotyping, a single nucleotide polymorphism receiving much attention recently, and its influence on lung cancer risk as well as nicotine dependence in a Chinese Han population. Our results showed that the heterozygous C/T genotype and minor allele T conferred a significant higher risk of lung cancer than the CC homozygotes and allele C (adjusted OR=2.25, 95% CI=1.04-4.89, P=0.040 and OR=2.18, 95% CI=1.02-4.67, P=0.045 respectively). However, no association between the smoking habit and the CHRNA3 rs1051730 polymorphism was observed in this study. The results suggested that the rs1051730 polymorphism may modify susceptibility to lung cancer via ...Continue Reading

References

Jul 31, 1998·Cancer Causes & Control : CCC·E De StefaniH Deneo-Pellegrini
Mar 10, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M L Janssen-HeijnenJ W Coebergh
Aug 11, 2007·International Journal of Epidemiology·Richard TaylorAnnette Dobson
Jun 4, 2008·The American Journal of Psychiatry·Laura Jean BierutAlison M Goate
Oct 30, 2008·Journal of the National Cancer Institute·Margaret R SpitzXifeng Wu
Sep 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan M SametCharles M Rudin
Nov 17, 2009·Carcinogenesis·Antonella Galvan, Tommaso A Dragani
Nov 18, 2009·Journal of the National Cancer Institute·Dalsu BarisDebra T Silverman
Jan 21, 2011·European Journal of Human Genetics : EJHG·Rossella SoriceDaniela Toniolo
May 7, 2011·American Journal of Otolaryngology·Parul SinhaWilliam M Mendenhall
Jul 28, 2011·Women's Health·Henry T Lynch, Jane F Lynch
Oct 6, 2011·Japanese Journal of Clinical Oncology·Keitaro MatsuoUNKNOWN Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
Nov 1, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jing ChenGang Wu

❮ Previous
Next ❯

Citations

Apr 14, 2016·Journal of Cancer Research and Therapeutics·Huiling SunShukui Wang
Feb 7, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenjing ZhouChao Chen
Apr 4, 2018·BMC Research Notes·Basim Mohammad AyeshAbdalla Assaf Abed
Dec 23, 2015·The International Journal of Biological Markers·Jie-Fei HanJin-Ji Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved