Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population

Schizophrenia Research
Nagahide TakahashiToshiya Inada

Abstract

It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p=0.0269), and with a 2 marker haplotype (p=0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p=0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.

References

Mar 21, 2003·The New England Journal of Medicine·Laurent TaupenotDaniel T O'Connor
Nov 4, 2004·Biological Psychiatry·Masashi IkedaNorio Ozaki

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Citations

Aug 25, 2011·Endocrine Reviews·Alessandro BartolomucciStephen R J Salton
Feb 19, 2013·Journal of Psychiatry & Neuroscience : JPN·Joel JakobssonMikael Landén
May 3, 2011·Journal of Neural Transmission·Michael WillisJosef Marksteiner
Apr 24, 2015·Molecular Neurobiology·Enrico CocchiAlessandro Serretti
Sep 27, 2014·Behavioural Brain Research·Daniel PeredaRicardo Borges
Jan 1, 2020·IUBMB Life·Fanny LaguerreMaité Montero-Hadjadje

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