Association Between Chronic Aspiration and Chronic Airway Infection with Pseudomonas aeruginosa and Other Gram-Negative Bacteria in Children with Cerebral Palsy

Lung
Christopher A GerdungThomas Kovesi

Abstract

Children with cerebral palsy (CP) are at an increased risk for aspiration, and subsequent pneumonia or pneumonitis. Pneumonia is a common cause of hospital admission, intensive care unit (ICU) admission, and death in patients with CP, and may disproportionately contribute to mortality. The role of respiratory microflora is unknown. This study examined the relationship between respiratory infections with Gram-negative bacteria (GNB), particularly Pseudomonas aeruginosa, and the frequency/severity of pneumonia hospitalization. Retrospective chart review of 69 patients with CP and hospitalization for pneumonia. Eligible patients required hospitalization for bacterial pneumonia, at least one respiratory culture, and fulfillment of Bax definition of CP. Group assignment was based on respiratory culture. Charts were analyzed for comorbid illness, hospitalization demographics, and disease severity. Children with isolation of P. aeruginosa or other GNB had increased frequency of ICU admission (77.4, 65.1, vs. 26.9 %, respectively, p < 0.01), intubation (45.2, 39.5 vs. 11.5 %, p = 0.02, p = 0.03 respectively), and large pleural effusions (37.5, vs. 0 %) than children without GNB. Children with isolation of GNB had more prolonged hospita...Continue Reading

References

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Citations

Mar 21, 2018·Archives of Disease in Childhood·Amanda Marie BlackmoreAndrew C Wilson
Jan 1, 2020·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Joanna ThomsonSamir S Shah
Jul 17, 2020·Frontiers in Pediatrics·Rachael MarpoleAndrew C Wilson
Apr 7, 2021·European Journal of Pediatrics·Elizabeth GregsonHeather E Elphick

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