Abstract
Children with cerebral palsy (CP) are at an increased risk for aspiration, and subsequent pneumonia or pneumonitis. Pneumonia is a common cause of hospital admission, intensive care unit (ICU) admission, and death in patients with CP, and may disproportionately contribute to mortality. The role of respiratory microflora is unknown. This study examined the relationship between respiratory infections with Gram-negative bacteria (GNB), particularly Pseudomonas aeruginosa, and the frequency/severity of pneumonia hospitalization. Retrospective chart review of 69 patients with CP and hospitalization for pneumonia. Eligible patients required hospitalization for bacterial pneumonia, at least one respiratory culture, and fulfillment of Bax definition of CP. Group assignment was based on respiratory culture. Charts were analyzed for comorbid illness, hospitalization demographics, and disease severity. Children with isolation of P. aeruginosa or other GNB had increased frequency of ICU admission (77.4, 65.1, vs. 26.9 %, respectively, p < 0.01), intubation (45.2, 39.5 vs. 11.5 %, p = 0.02, p = 0.03 respectively), and large pleural effusions (37.5, vs. 0 %) than children without GNB. Children with isolation of GNB had more prolonged hospita...Continue Reading
References
Aug 1, 1991·The American Review of Respiratory Disease·B W RamseyK Harris
Apr 1, 1971·Clinical Pediatrics·K A HableE C Herrmann
Feb 1, 1995·The Journal of Pediatrics·H ZarA Prince
Oct 1, 1996·Pediatric Radiology·R E WrightC A Carson
Feb 9, 2000·Archives of Pediatrics & Adolescent Medicine·A F OwayedE E Wang
Aug 19, 2000·The American Journal of Gastroenterology·C J BöhmerS G Meuwissen
May 1, 2001·Journal of Paediatrics and Child Health·D S ReddihoughJ E Walstab
May 9, 2001·The Journal of Pediatrics·G M NixonK Grimwood
Jul 12, 2002·Pediatric Pulmonology·Julia EmersonRonald L Gibson
Aug 20, 2005·Developmental Medicine and Child Neurology·Martin BaxUNKNOWN Executive Committee for the Definition of Cerebral Palsy
May 30, 2007·Archives of Physical Medicine and Rehabilitation·Nancy L YoungJack I Williams
Oct 22, 2008·Journal of Biomedical Informatics·Paul A HarrisJose G Conde
Dec 6, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kentigern ThorburnHendrick K F van Saene
Jul 21, 2010·Pediatrics·Grace E LeeSamir S Shah
Dec 29, 2010·Archives of Physical Medicine and Rehabilitation·Nancy L YoungJohn Wedge
Mar 26, 2011·Chest·Kelly A WeirAnne B Chang
Sep 21, 2011·European Journal of Pediatrics·Corrie E ErasmusPeter H Jongerius
Oct 5, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Sanja StanojevicFelix Ratjen
Dec 11, 2013·Hospital Pediatrics·Erica Y Chung, Jeremy Yardley
Aug 20, 2014·Pediatrics·Kavita ParikhSamir S Shah
Citations
Jul 9, 2016·Acta Paediatrica·Liat Ashkenazi-HoffnungDario Prais
Mar 21, 2018·Archives of Disease in Childhood·Amanda Marie BlackmoreAndrew C Wilson
Feb 18, 2017·Breathe·Marijke Proesmans
Jan 1, 2020·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Joanna ThomsonSamir S Shah
Jul 31, 2019·ERJ Open Research·Maximilian EckerlandFlorian Stehling
Jan 18, 2018·Hospital Pediatrics·Christopher J RussellSusan Wu
Apr 13, 2019·Trials·Lilian Chrystiane GiannasiMônica F Gomes
Sep 25, 2017·Pediatric Pulmonology·Sharon A McGrath-MorrowJoseph M Collaco
Nov 2, 2019·Lung·Christopher J RussellMichael N Neely
Jul 17, 2020·Frontiers in Pediatrics·Rachael MarpoleAndrew C Wilson
Apr 7, 2021·European Journal of Pediatrics·Elizabeth GregsonHeather E Elphick