Association between chronic hepatitis C virus infection and high levels of circulating N-terminal pro-brain natriuretic peptide.

Endocrine
Kyoko OkadaJun Hayashi

Abstract

The association between HCV infection and myocardial disorders remains unclear. This study aimed to assess whether or not HCV infection influences myocardial dysfunction by the use of NT-proBNP, a sensitive marker of myocardial dysfunction. A total of 198 participants [99 patients with chronic HCV infection (aged 46-68 years) and 99 anti-HCV-negative sex and age matched controls] were examined. Serum HCV-RNA level and HCV genotype were tested and liver biopsy was done only for the patient group. The NT-proBNP concentration of the HCV patients (mean 71.6 ± 79.1 pg/ml; median 46.0 pg/ml, range 5.0-400.0) was significantly higher than that of the controls (mean 39.8 ± 24.4 pg/ml; median 35.8 pg/ml, range 7.0-108.0) (P < 0.05). 20.0 % of the HCV patients and 0.6 % of the controls had high NT-proBNP (higher than 125 pg/ml; the single cut off point for patients under 75 years of age) (P < 0.05). Stepwise multiple regression analysis revealed that chronic HCV infection was independently correlated with NT-proBNP level after adjustment for parameters that might influence NT-proBNP (P = 0.005). Our data suggest that chronic HCV infection is associated with increased NT-proBNP, indicating that chronic HCV infection might induce myocardia...Continue Reading

References

Nov 1, 1995·Circulation·A MatsumoriS Sasayama
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J HayashiS Kashiwagi
Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Nov 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hashem B El-SeragLinda Rabeneck
Feb 13, 2004·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
Jul 6, 2004·Journal of the American College of Cardiology·Robert E EckartUNKNOWN Department of Defense Smallpox Vaccination Clinical Evaluation Team
Apr 12, 2005·The American Journal of Cardiology·James L JanuzziKent B Lewandrowski
Feb 2, 2006·Circulation·Kenneth L Baughman
Mar 8, 2006·World Journal of Gastroenterology : WJG·Norihiro FurusyoUNKNOWN Kyushu University Liver Disease Study Group
May 9, 2006·Journal of Cardiac Failure·Akira MatsumoriJay W Mason
Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alessandro AntonelliPoupak Fallahi

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Norihiro FurusyoJun Hayashi
Revista Da Sociedade Brasileira De Medicina Tropical
Amanda Alves FecuryLuisa Caricio Martins
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
J CrespoF Pons-Romero
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Vincenzo Bossi, Claudio Galli
© 2021 Meta ULC. All rights reserved