Association between chronic liver and colon inflammation during the development of murine syngeneic graft-versus-host disease.

American Journal of Physiology. Gastrointestinal and Liver Physiology
J Anthony BrandonJ S Bryson

Abstract

The murine model of cyclosporine A (CsA)-induced syngeneic graft-versus-host disease (SGVHD) is a bone marrow (BM) transplantation model that develops chronic colon inflammation identical to other murine models of CD4(+) T cell-mediated colitis. Interestingly, SGVHD animals develop chronic liver lesions that are similar to the early peribiliary inflammatory stages of clinical chronic liver disease, which is frequently associated with inflammatory bowel disease (IBD). Therefore, studies were initiated to investigate the chronic liver inflammation that develops in the SGVHD model. To induce SGVHD, mice were lethally irradiated, reconstituted with syngeneic BM, and treated with CsA. All of the SGVHD animals that developed colitis also develop chronic liver inflammation. Liver samples from control and SGVHD animals were monitored for tissue pathology, RNA for inflammatory mediators, and phenotypic analysis and in vitro reactivity of the inflammatory infiltrate. Diseased animals developed lesions of intrahepatic and extrahepatic bile ducts. Elevated levels of mRNA for molecules associated with chronic liver inflammation, including mucosal cellular adhesion molecule -1, the chemokines CCL25, CCL28, CCR9, and T(H)1- and T(H)17-associa...Continue Reading

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Citations

Jun 29, 2016·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·R-G Mihăilă
Sep 14, 2011·Chimerism·J Scott BrysonAlan M Kaplan
Oct 8, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Soshi MuramatsuMasakazu Ichinose
Feb 8, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Anthony BrandonJ Scott Bryson

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