PMID: 2092299Dec 1, 1990Paper

Association between circulating antigen and parasite load in a model filarial system, Acanthocheilonema viteae in jirds

Parasitology
W HarnettR M Parkhouse

Abstract

Jirds (Meriones libycus) were infected with various numbers of Acanthocheilonema viteae L3 stage parasites. During the course of the ensuing 16 weeks, blood samples were collected at 2 weekly intervals and the amount of the major parasite excretory-secretory product (E-S 62) and antibodies directed against it measured. After 16 weeks, animals were sacrificed and the size of the mature worm burden established. In spite of interaction between E-S 62 and host antibody, a statistically significant relationship was found to exist between the amount of E-S 62 present in the bloodstream and the size of the parasite load. It is suggested that the detectable antigen level is more influenced by the size of the worm burden than the presence of antibody and that antibody is only likely to affect adversely antigen measurement in situations where the amount released is relatively low. Examples of this are early in infection and in low-level infections. These ideas are discussed in relation to the development and assessment of serological assays which attempt to predict parasite burden in human filarial infections.

References

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Citations

Jul 1, 1994·International Journal for Parasitology·W HarnettR M Parkhouse
Dec 10, 1999·Molecular and Biochemical Parasitology·W HarnettH Brzeski
Oct 16, 2015·Trends in Parasitology·Johnny VlaminckGary J Weil
Sep 3, 2008·Parasite Immunology·W Harnett, M M Harnett
Jul 6, 2004·Immunology Letters·William HarnettMargaret M Harnett
Apr 27, 2016·The American Journal of Tropical Medicine and Hygiene·Cédric B ChesnaisMichel Boussinesq
Jan 9, 2019·The Cochrane Database of Systematic Reviews·Cara L MacfarlanePaul Garner

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