Association between circulating levels of heat-shock protein 27 and aggressive periodontitis

Cell Stress & Chaperones
Frank KaiserL Nibali

Abstract

Heat-shock protein (Hsp) 27 is a major intracellular molecular chaperone and controller of intracellular responses to inflammatory signals. In the extracellular space, recombinant Hsp27 has been described to exert anti-inflammatory activities. The aim of this study was to assess the association between circulating levels of Hsp27 and different types of periodontitis. Pro- and anti-inflammatory cytokines and the stress proteins Hsp27 and Hsp60 with proposed anti- and pro-inflammatory properties, respectively, were measured by two-site ELISA in the serum of patients with aggressive periodontitis (AgP, n = 30), chronic periodontitis (CP, n = 29) and periodontally healthy controls (H, n = 28). Furthermore, Hsp27 and Hsp60 levels were also measured longitudinally in 12 AgP patients at 6 time points up to 3 months after treatment. AgP patients had lower levels of Hsp27 compared to CP patients and healthy subjects (adjusted one-way ANOVA, p < 0.001, followed by post hoc Tukey HSD comparisons), while no differences in levels of Hsp60 or cytokines between the three groups were detected. In CP patients and H subjects, the systemic Hsp27 levels correlated with Hsp60 (r = 0.43, p < 0.001; r = 0.59, p < 0.001, respectively) and with pro-inf...Continue Reading

References

Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A K DeC Miller-Graziano
Jul 10, 2002·Periodontology 2000·Jasim M Albandar, Eduardo M B Tinoco
Jan 14, 2004·Periodontology 2000·Gary C Armitage
Mar 23, 2004·Annual Review of Immunology·Georg WickQingbo Xu
Jul 13, 2004·Current Opinion in Immunology·Gabriel S PanayiBrian Henderson
Jul 26, 2005·Cell Stress & Chaperones·Daniel R Ciocca, Stuart K Calderwood
Dec 5, 2006·Cardiovascular Research·Alireza Shamaei-TousiBrian Henderson
Sep 8, 2007·European Journal of Immunology·Krzysztof LaudanskiCarol Miller-Graziano
Apr 21, 2010·Periodontology 2000·Gary C Armitage, Mary P Cullinan
Apr 21, 2010·Periodontology 2000·Michael SmithMary P Cullinan
Oct 29, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Diana Lebherz-EichingerGeorg A Roth
Jan 5, 2012·Cell Stress & Chaperones·Brian Henderson, A Graham Pockley
Jan 18, 2012·Journal of Periodontology·Sema BecerikGülnur Emingil
Apr 24, 2012·European Journal of Clinical Investigation·Harald MischakAntonia Vlahou
Jun 1, 2012·Canadian Journal of Physiology and Pharmacology·Surya Ramachandran, C C Kartha
Sep 1, 2012·Journal of Dental Research·P I EkeR J Genco
Sep 5, 2012·Acta Odontologica Scandinavica·Letícia Grando MattuellaLetícia Algarves Miranda
Feb 27, 2013·Current Pharmaceutical Design·Michael BukrinskyDmitri Sviridov
Sep 13, 2013·Nature Reviews. Molecular Cell Biology·Helen Saibil
Oct 15, 2013·Journal of Dental Research·M KebschullP N Papapanou
Dec 20, 2013·The Journal of Experimental Biology·Virginija JovaisaiteJohan Auwerx
Jan 21, 2014·Biochimica Et Biophysica Acta·Wen-An WangMarek Michalak
Aug 8, 2014·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·R Ramya NethravathyT S S Kumar
Jan 26, 2017·Cytokine·Panagiotis PapadopoulosSotirios Tsiodras
Dec 6, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Graham Pockley, Brian Henderson

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Citations

May 3, 2020·International Journal of Environmental Research and Public Health·Marco TatulloDanila De Vito

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Methods Mentioned

BETA
protein-folding
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Revelation
SPSS

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