Association between circulating monocyte chemoattractant protein-1 and urinary albumin excretion in nonobese Type 2 diabetic patients

Journal of Diabetes and Its Complications
Kohzo TakebayashiToshihiko Inukai

Abstract

In 70 nonobese inpatients with Type 2 diabetes [body mass index (BMI): 24.0+/-4.4 kg/m(2)], we examined circulating monocyte chemoattractant protein (MCP) -1 as a candidate marker of atherosclerosis by comparison with established markers: serum high-sensitivity C-reactive protein (hsCRP), plasma fibrinogen, and combined carotid artery intimal-medial thickness (IMT). In addition, an association was sought between circulating MCP-1 and urinary albumin excretion (UAE), reflecting diabetic renal microangiopathy. Serum MCP-1 was determined by enzyme-linked immunosorbent assay (ELISA). Patients were grouped by UAE: normoalbuminuria, below 30 mg/g of creatinine (Cr); microalbuminuria, 30 to 300 mg/g Cr; or macroalbuminuria, over 300 mg/g Cr. Serum MCP-1 for all participants, men, and women was 280.0+/-78.9, 269.0+/-68.8, and 294.9+/-87.9 pg/ml, respectively, showing no difference between genders. No correlation was noted between MCP-1 and hsCRP, fibrinogen, or carotid artery IMT. No correlation of MCP-1 was observed with age, duration of diabetes, fasting plasma glucose (FPG), hemoglobin (Hb) A(1C), BMI, diastolic blood pressure (DBP), or serum lipid concentrations, but significant correlations were found with systolic blood pressure ...Continue Reading

References

Oct 1, 1991·The Journal of Clinical Investigation·N A NelkenJ N Wilcox
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S Ylä-HerttualaD Steinberg
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E A RobinsonE Appella
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y J ShyyS Chien
Mar 25, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G KrishnaswamyD S Chi
Nov 24, 1999·Atherosclerosis·T J Reape, P H Groot
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A FestaS M Haffner

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Citations

Nov 23, 2006·Current Diabetes Reports·Carmen Mora, Juan F Navarro
Aug 26, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Abdullah TaslipinarMustafa Kutlu
Oct 16, 2007·Annals of Medicine·Damiano BaldassarreCesare R Sirtori
Sep 18, 2012·Journal of Diabetes and Its Complications·S M TitanR Zatz
Dec 23, 2008·Diabetes Research and Clinical Practice·Qiu-yue Wang, Fen-qin Chen
Oct 10, 2009·British Journal of Pharmacology·J C RussellS D Proctor
Mar 12, 2010·Diabetes/metabolism Research and Reviews·Agnès MathesonBradley J Walsh
May 9, 2012·Diabetes Research and Clinical Practice·Michiaki FukuiNaoto Nakamura
Apr 24, 2015·Biological Research for Nursing·Hua Liang
Nov 6, 2013·The American Journal of Tropical Medicine and Hygiene·Alba OtoniJosé Roberto Lambertucci
May 23, 2012·The Journal of International Medical Research·T NakamuraS I Yamagishi
Jan 19, 2012·World Journal of Diabetes·Desirée Luis-RodríguezJuan F Navarro-González
Aug 2, 2018·American Journal of Physiology. Renal Physiology·Ulf MichgehlThomas Weide
Apr 9, 2009·Nature Reviews. Cardiology·Varun AgrawalPeter A McCullough
Jun 22, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Irfan DegirmenciHasan Veysi Gunes
May 29, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·James C RussellSpencer D Proctor
Nov 30, 2010·Journal of Immunoassay & Immunochemistry·Jingfang LiuBingyin Shi
Nov 17, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jingping HuZhiguang Zhou
Feb 10, 2009·Clinical Science·Antonio RiveroJuan F Navarro-González
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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