Association between colistin dose and development of nephrotoxicity

Critical Care Medicine
Yu-Ji LeeSeong Cho

Abstract

To investigate the development of nephrotoxicity associated with colistin dose, and whether this relationship differs depending on renal function. A retrospective cohort study of patients who received intravenous colistin to treat infections caused by extensively drug-resistant Gram-negative microorganisms. Adult patients receiving colistin for 72 hours or longer were included in this study. Patients who received renal replacement therapy at baseline or were administered colistin for less than 3 days were excluded. Colistin-induced nephrotoxicity was defined as a doubling of baseline serum creatinine. Colistin dosing was evaluated based on both actual body weight and ideal body weight. Single general hospital between 2010 and 2013. A total number of 475 patients received colistin therapy. Of these patients, 329 met the inclusion criteria and were included in the analysis. None. One hundred forty-three patients (43.5%) experienced nephrotoxicity during colistin treatment. The median onset time of nephrotoxicity was 6 days (interquartile range, 4-8 days). The patients with nephrotoxicity were older. Hematocrit and serum albumin levels were lower in patients with nephrotoxicity. Median daily dosing of colistin based on ideal body ...Continue Reading

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