Association between colonic diverticular disease and colorectal cancer: a nationwide population-based study

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Wen-Yen HuangChia-Hung Kao

Abstract

We investigated whether a diagnosis of colonic diverticular disease is associated with an increased risk for subsequent development of colorectal cancer (CRC) in a nationwide population-based retrospective study. We identified 41,359 individuals diagnosed with colonic diverticular disease as inpatients from 2000 through 2009 from the Taiwan National Health Insurance Research Database (study cohort) and collected data for 165,436 randomly selected additional subjects, matched by sex, age, and baseline year (comparison cohort). Data were collected until individuals developed CRC or withdrew from the National Health Insurance system, or until December 31, 2010. Cumulative incidences and hazard ratios (HRs) of CRC development were determined. To assess for ascertainment bias, we conducted an analysis excluding the first 12 months of follow-up evaluation. The risk of CRC was significantly higher in the study cohort than in the comparison cohort (HR adjusted for age, sex, and comorbidities, 4.54; 95% confidence interval, 4.19-4.91; P < .0001). In a sensitivity analysis, we excluded the first 12 months of follow-up evaluation after a diagnosis of colonic diverticular disease; subsequent incidence rates for CRC in the study and compari...Continue Reading

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Citations

Feb 27, 2016·Scandinavian Journal of Gastroenterology·Martin H HvolrisHans J Nielsen
Jul 28, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Veeravich JaruvongvanichSikarin Upala
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Sep 18, 2020·The British Journal of Radiology·Nicola FlorLuca Maggi
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Dec 25, 2019·Gastroenterology Research and Practice·Fadi Abu BakerYael Kopelman
Jan 29, 2021·Medicina·Angelo ViscidoGiovanni Latella

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