Association between colonic diverticulosis and bowel symptoms: A case-control study of 1629 Asian patients

Journal of Gastroenterology and Hepatology
Naoyoshi NagataNaomi Uemura

Abstract

It remains unclear whether diverticulosis, absent inflammation, is responsible for chronic bowel symptoms. We examined the association between bowel symptoms and asymptomatic diverticulosis. This case-control study included 543 patients with diverticulosis and 1086 age and sex-matched controls (1:2) without diverticulosis on screening colonoscopy. Eleven symptoms (abdominal discomfort, hunger discomfort, borborygmus, abdominal distension, flatus, constipation, diarrhea, loose stools, hard stools, fecal urgency, and incomplete evacuation) were evaluated using a gastrointestinal symptoms rating scale (GSRS) at baseline and second questionnaire. Associations between diverticulosis and symptoms were estimated using odds ratios (ORs) and 95 confidence interval (CI). In multivariate analysis, constipation (OR, 0.85 [0.78-0.93]) and hard stools (OR, 0.86 [0.78-0.94]) were negatively associated with diverticulosis. The other nine symptoms showed no association with diverticulosis. Diverticulosis was negatively associated with constipation (OR, 0.93 [0.74-0.93]), hard stools (OR, 0.85 [0.76-0.96]), and incomplete evacuation (OR, 0.88 [0.79-0.99]) in males, and positively associated with diarrhea (OR, 1.39 [1.14-1.69]) and loose stools (...Continue Reading

References

Jul 1, 1982·Digestive Diseases and Sciences·W G ThompsonR C Nair
May 20, 2003·Alimentary Pharmacology & Therapeutics·C QuanM Horowitz
Oct 9, 2003·Scandinavian Journal of Gastroenterology·I K WiklundJ Naesdal
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Jul 27, 2006·Journal of Gastroenterology·Akiko ShiotaniToku Takahashi
Feb 16, 2008·International Journal of Colorectal Disease·Santhini Jeyarajah, Savvas Papagrigoriadis
Jul 23, 2009·The American Journal of Gastroenterology·Jane Møller HansenOve B Schaffalitzky de Muckadell
Oct 29, 2009·The American Journal of Gastroenterology·Hye-Kyung JungNicholas J Talley
Dec 3, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M KuboT Arakawa
Dec 17, 2010·Alimentary Pharmacology & Therapeutics·J Y KangA G Lim
Nov 9, 2011·Gastroenterology·Anne F PeeryRobert S Sandler
May 11, 2012·Digestive Diseases·Lisa L Strate
Jul 11, 2012·The American Journal of Gastroenterology·Lisa L StrateBrennan M R Spiegel
Mar 26, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Erica CohenBrennan Spiegel
May 15, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anne F Peery, Robert S Sandler
Jul 31, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anne F PeeryJohn A Baron
Jun 20, 2014·World Journal of Gastroenterology : WJG·Mathieu Meleine, Julien Matricon
Oct 22, 2014·The American Journal of Gastroenterology·Eiji YamadaAtsushi Nakajima

❮ Previous
Next ❯

Citations

Feb 27, 2016·Scandinavian Journal of Gastroenterology·Martin H HvolrisHans J Nielsen
Jan 13, 2019·Journal of Gastroenterology and Hepatology·Michiko WadaTakanori Kanai
Apr 21, 2017·Journal of Gastroenterology and Hepatology·Eiji YamadaAtsushi Nakajima
Apr 18, 2018·World Journal of Gastroenterology : WJG·Naohiro YanagisawaNaomi Uemura
Jul 1, 2020·Journal of Gastroenterology and Hepatology·Yu Sen Alex SohKok-Ann Gwee
Jul 22, 2021·Annals of Coloproctology·Greg A TurnerFrank A Frizelle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.