Association between colorectal cancer and thiazolidinediones administration in a case-control study

BioMedicine
Kuan-Fu LiaoShih-Wei Lai

Abstract

This study was designed to assess whether there was an association between colorectal cancer and thiazolidinediones use. A population-based case-control study was performed using the database of the Taiwan National Health Insurance Program. The case group consisted of 20218 type 2 diabetic subjects aged 20 to 84 years with newly diagnosed colorectal cancer between 2000 and 2011. The date of a subject being diagnosed with colorectal cancer was defined as the index date. The control group consisted of 20218 randomly selected type 2 diabetic subjects aged 20 to 84 years without colorectal cancer between 2000 and 2011. A subject who had at least a prescription of thiazolidinediones before the index date was defined as "ever used". A subject who did not have a prescription of thiazolidinediones before the index date was defined as "never used". The odds ratio (OR) and 95% confidence interval (CI) was used to estimate the association between colorectal cancer and thiazolidinediones use by the multivariable logistic regression model. After adjustment for potential confounders, the odds of thiazolidinediones use in cases with colorectal cancer were lower than the odds of thiazolidinediones use in subjects without colorectal cancer (adj...Continue Reading

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Citations

May 10, 2019·Cancers·Feda H Hamdan, Steven A Johnsen
Sep 15, 2019·Journal of the American Geriatrics Society·Shih-Wei Lai, Cheng-Li Lin
Nov 7, 2019·International Journal of Evidence-based Healthcare·Shih-Wei LaiKuan-Fu Liao
Jun 2, 2020·International Journal of Clinical Practice·Shih-Wei LaiKuan-Fu Liao
Aug 7, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Shih-Wei LaiKuan-Fu Liao

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