Association between common genetic variants of α2A-, α2B-, and α2C-adrenergic receptors and ischemic stroke

Clinical Neurology and Neurosurgery
Seung-Hun OhNam-Keun Kim

Abstract

The alpha2-adrenergic receptor (α2-AR) mediates physiological responses to endogenous catecholamine, and genetic variants of α2-AR may predispose to clinical vascular diseases. We evaluated whether common genetic variants of each three subtype of alpha2-adrenergic receptor (ADRA2A, ADRA2B, and ADRA2C) were associated with ischemic stroke. A total of 616 patients with ischemic stroke and 512 controls were genotyped for the ADRA2A 1780G>A, ADRA2B 301-303 I/D, and ADRA2C 322-325 I/D polymorphisms. Logistic regression analyses, adjusting for multiple comparisons, were used to determine the association between the minor allele of each of three ADRA2 genes and the risk of ischemic stroke and pathophysiological subtypes. The ADRA2B 301-303 D allele was more prevalent in the stroke group, compared to controls (DD vs. II, OR: 1.78, 95% CI: 1.18-2.69; recessive, OR: 1.55, 95% CI: 1.06-2.26). A subgroup analysis revealed that this association was found only in the small vessel diseases (SVD) type (DD vs. II, OR: 1.92, 95% CI: 1.11-3.33). The ADRA2A and ADRA2C polymorphisms did not contribute to an increased risk of ischemic stroke or any pathophysiological subtype. The ADRA2B 301-303 D allele confers an increased risk of overall ischemic ...Continue Reading

References

Dec 18, 1968·Acta Neuropathologica·C M Fisher
Jun 1, 1997·Trends in Pharmacological Sciences·E MacDonaldM Scheinin
May 26, 1998·Seminars in Cell & Developmental Biology·S S Ferguson, M G Caron
Aug 26, 2000·Brain : a Journal of Neurology·A Hassan, H S Markus
Sep 7, 2001·Trends in Pharmacological Sciences·K M Small, S B Liggett
Oct 30, 2001·Behavioural Brain Research·Y BenjaminiI Golani
Oct 11, 2002·The New England Journal of Medicine·Kersten M SmallStephen B Liggett
Jan 22, 2003·Journal of the American College of Cardiology·Amir SnapirPekka J Karhunen
Nov 18, 2004·Journal of the National Cancer Institute·Hans-Hermann Dubben
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kersten M SmallStephen B Liggett
Dec 21, 2006·American Journal of Preventive Medicine·Byung-Chul LeeUNKNOWN Korean Stroke Registry
Aug 14, 2009·The New England Journal of Medicine·Jongoh Kim, Young Kwang Chae
Dec 8, 2009·Science·Anders H RosengrenErik Renström

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