Association between comorbid cancer and outcomes among admissions for acute ischemic stroke receiving systemic thrombolysis

International Journal of Stroke : Official Journal of the International Stroke Society
Erin R Weeda, Nicole Bohm

Abstract

The impact of cancer on outcomes was not assessed in major trials of systemic thrombolysis in acute ischemic stroke. To evaluate the association between comorbid cancer and hospital outcomes among patients receiving systemic thrombolysis for the treatment of acute ischemic stroke. The 2013 and 2014 United States National Inpatient Sample was used to identify adult patients hospitalized for acute ischemic stroke who received systemic thrombolysis. Identified admissions were stratified into two cohorts based on the presence or absence of comorbid cancer. Multivariable logistic regression was performed to determine the association between comorbid cancer and the odds of in-hospital mortality and intracerebral hemorrhage after adjustment for age ≥75 years and comorbid atrial fibrillation. A total of 13,993 acute ischemic stroke admissions were treated with systemic thrombolysis. Of these, 3.0% ( n = 416) had comorbid cancer. The overall incidence of in-hospital mortality was 7.0% and intracerebral hemorrhage occurred in 7.6% of patients. Upon multivariable adjustment, comorbid cancer was not associated with an increased odds of in-hospital mortality (odds ratio = 1.24; 95% confidence interval = 0.88-1.76). However, the adjusted odd...Continue Reading

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Citations

Dec 24, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·Jocelyn Owusu-GuhaDaniel Addison
May 21, 2020·Journal of Clinical Medicine·Aleksander Lukasiewicz
Mar 21, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Asma Akbar LadakAhmed Itrat
Mar 30, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Mi-Yeon EunJin-Man Jung
Jun 4, 2021·Scientific Reports·Giovanni MerlinoMariarosaria Valente

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