Association between comorbidity burden and rapid cognitive decline in individuals with mild to moderate Alzheimer's disease

Journal of the American Geriatrics Society
Lauren AubertLaure de Decker

Abstract

To determine the association between rapid cognitive decline and burden of comorbidities as assessed using the Charlson Comorbidity Index in individuals aged 65 and older with Alzheimer's disease (AD). Retrospective cohort study. Memory clinic at the University Hospital of Nantes. Individuals aged 65 and older with AD (n=170). Subjects were followed for 1 year. Rapid cognitive decline was defined as a decrease of 3 or more points on the Mini-Mental State Examination per 12-month period. Variables studied were the Charlson Comorbidity Index (measure of comorbidity burden), age, sex, AD stage, type of residence (living at home or not), presence of caregiver, functional abilities (Lawton and Katz scales), risk of malnutrition or depression, and intercurrent events (hospitalization or initiating home care). Rapid cognitive decline at 1-year follow-up occurred in 65 subjects (38.2%). In fully adjusted logistic regression analysis, Charlson Comorbidity Index was significantly associated with rapid cognitive decline (odds ratio (OR)=1.30, P=.03). Moderate stage of AD (OR=2.07, P=.04) and living at home (OR=4.17, P=.04) were also associated with rapid cognitive decline. Comorbidity burden was associated with rapid cognitive decline in ...Continue Reading

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Citations

Mar 13, 2016·Neuroscience and Biobehavioral Reviews·David Baglietto-VargasFrank M LaFerla
Jun 2, 2018·International Journal of Geriatric Psychiatry·Iracema LeroiTaro Sugihara
Mar 6, 2018·Journal of Alzheimer's Disease : JAD·Alessandra C MartiniFrank M LaFerla
Jun 30, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Hiroyuki Kobayashi, Heii Arai
Oct 8, 2015·Journal of Alzheimer's Disease : JAD·Maja Sparre-Sørensen, Gustav Kristensen
Oct 2, 2017·Current Treatment Options in Neurology·Supriya Mahajan, Brian S Appleby
Feb 23, 2020·Journal of Diabetes Research·Yanan SunXu He
Jul 4, 2018·Journal of Alzheimer's Disease : JAD·Jagan A PillaiJames B Leverenz
Feb 3, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kan Z GianattasioUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 20, 2021·International Journal of Geriatric Psychiatry·Trine Holt EdwinAnne-Brita Knapskog
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·David A Loeffler
Oct 15, 2020·International Journal of Molecular Sciences·Vidyasagar Naik BukkeTommaso Cassano
Jun 3, 2021·Cells·Jesús BurilloCarlos Guillén
Jul 31, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lori L Beason-HeldSusan M Resnick

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