Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies

Molecular Genetics & Genomic Medicine
Harika Gozde Gozukara Bag

Abstract

There are many studies with different results that examine the association between Catechol-O-MethylTransferase (COMT) gene single-nucleotide polymorphisms (SNPs) and schizophrenia. In this study, the aim was to conduct a meta-analysis to achieve a pooled effect size of the association between COMT gene rs165599 SNP and schizophrenia. Odds ratio (OR) was used as an effect size to determine the association between schizophrenia and the SNP. The pooled ORs were achieved under four different genetic models. When the heterogeneity among studies was high the DerSimonian-Laird random-effects model, otherwise the Mantel-Haenszel fixed-effects model was used. Publication bias was evaluated by Egger's test. Under different genetic models no statistically significant association was found between rs165599 SNP and schizophrenia by meta-analyses consist of 20 independent studies. There was high heterogeneity among studies, for the possible reason the population differences, although the subgroup analyzes reduced the heterogeneity, no association was obtained. However, the sex-specific estimation of the females showed that to be a G allele carrier is a risk factor for schizophrenia (OR = 1.366 [95% confidence interval = 1.094-1.706]) compar...Continue Reading

References

May 1, 1997·Molecular Psychiatry·M Karayiorgou, J A Gogos
Oct 26, 1999·Archives of General Psychiatry·K C MurphyM J Owen
May 23, 2001·Psychiatry Research·M de ChaldéeJ Mallet
Nov 19, 2003·European Journal of Pharmacology·David A Collier, Tao Li
Apr 12, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Rui YuJi-Cheng Li
Jan 1, 2008·Schizophrenia Research·Lourdes MartorellElisabet Vilella
Mar 31, 2009·Schizophrenia Research·Tomo OkochiNakao Iwata
Apr 17, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yi-Ling ChienHai-Gwo Hwu
May 22, 2010·Journal of Psychiatric Research·Javier CostasManuel Arrojo
Jun 19, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Galen E B WrightLouise Warnich
Sep 12, 2012·Genetic Testing and Molecular Biomarkers·Fuquan ZhangDai Zhang
Feb 9, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ryoko HigashiyamaHeii Arai
Mar 10, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Brian Dean, Elizabeth Scarr
Mar 9, 2017·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Camila T MatsuzakaRodrigo A Bressan
Jun 14, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Steven Taylor

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