Association between CXCL9/10 polymorphisms and acute rejection of liver allograft

Medicine
Ana OstojicAnna Mrzljak

Abstract

While increased serum concentrations of CXCL9/10 are associated with acute cellular rejection (ACR) occurrence, the association between CXCL9/10 single nucleotide polymorphisms (SNPs) and ACR after liver transplantation (LT) remains unknown.In the present case-control study, polymorphisms of CXCL9 (rs10336) and CXCL10 (rs3921) were determined by polymerase chain reaction in 215 liver transplant recipients. ACR was defined as biopsy proven within 6 months after LT. As selected SNPs were in 3'-UTR region, their possible association with protein synthesis was assessed by measuring the plasma concentration of CXCL9/10 in a cohort of 40 new transplant patients using ELISA.There was no association between CXCL9/10 genotypes and overall incidence of ACR. However, patients with CXCL9 genotype AA developed ACR earlier than patients with GG genotype (P = .003), with similar results for CXCL10 gene (CC vs GG; P = .005). There was no statistically significant difference in plasma concentrations of CXCL9/10 between the rejectors and the non-rejectors. Of note, patients with AA CXCL9 genotype had significantly higher CXCL9 plasma concentrations than patients with AG (P = .01) or GG genotype (P = .045).In conclusion, the SNPs of CXCL9 (rs1033...Continue Reading

References

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Citations

Apr 8, 2020·World Journal of Gastroenterology : WJG·Tomislav KelavaAnna Mrzljak
Jun 9, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Taisa J KohutBrendan J Keating
Jan 22, 2021·Pathogens and Disease·Mariana Cavalheiro MagriFátima Mitiko Tengan

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Methods Mentioned

BETA
biopsies
ELISA

Software Mentioned

GraphPad Prism
GraphPad
R
SNPStats

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