Association between CYP2C19 Polymorphisms and Outcomes in Cerebral Endovascular Therapy.

AJNR. American Journal of Neuroradiology
M LinBernard Yan

Abstract

Differing responses to clopidogrel following endovascular treatment of cerebrovascular diseases may increase the risk of vascular complications. CYP2C19 gene polymorphisms influence clopidogrel activity. We aimed to study the clinical impact of CYP2C19 gene polymorphisms in patients undergoing endovascular treatment. This was a prospective, longitudinal, observational study. Information on demographics and cerebrovascular status was collected as baseline. Clopidogrel response was tested by the VerifyNow P2Y12 assay. CYP2C19 genotyping was undertaken by polymerase chain reaction-restriction fragment length polymorphism. Three-month follow-up data included vascular complications, mortality, and modified Rankin Scale score. Associations were investigated among CYP2C19 genotypes, clopidogrel responsiveness, and clinical outcomes. One hundred and eight participants were included. Median age was 56 years (interquartile range, 48.8-65.0 years), and 35 (32.4%) were male. Forty-four participants were classified into group 1 (homozygous CYP2C19*1/*1); 31, into group 2 (25 with CYP2C19*1/*2, two with CYP2C19*1/*3, three with CYP2C19*3/*3, one with CYP2C19*2/*3); 28, into group 3 (24 with CYP2C19*1/*17, four with CYP2C19*17/*17); and 5, in...Continue Reading

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Citations

Jul 1, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Irina PiatkovMark McLean
Jun 20, 2018·Clinical Pharmacology and Therapeutics·Ljiljana Rakicevic, Aleksandra Nestorovic
Feb 6, 2021·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Axel RosengartChristoph J Griessenauer
May 23, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Subhashaan SreedharanBernard Yan
Aug 31, 2021·Current Reviews in Clinical and Experimental Pharmacology·Ehab S El Desoky

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