Abstract
Differing responses to clopidogrel following endovascular treatment of cerebrovascular diseases may increase the risk of vascular complications. CYP2C19 gene polymorphisms influence clopidogrel activity. We aimed to study the clinical impact of CYP2C19 gene polymorphisms in patients undergoing endovascular treatment. This was a prospective, longitudinal, observational study. Information on demographics and cerebrovascular status was collected as baseline. Clopidogrel response was tested by the VerifyNow P2Y12 assay. CYP2C19 genotyping was undertaken by polymerase chain reaction-restriction fragment length polymorphism. Three-month follow-up data included vascular complications, mortality, and modified Rankin Scale score. Associations were investigated among CYP2C19 genotypes, clopidogrel responsiveness, and clinical outcomes. One hundred and eight participants were included. Median age was 56 years (interquartile range, 48.8-65.0 years), and 35 (32.4%) were male. Forty-four participants were classified into group 1 (homozygous CYP2C19*1/*1); 31, into group 2 (25 with CYP2C19*1/*2, two with CYP2C19*1/*3, three with CYP2C19*3/*3, one with CYP2C19*2/*3); 28, into group 3 (24 with CYP2C19*1/*17, four with CYP2C19*17/*17); and 5, in...Continue Reading
References
Nov 5, 2002·Lancet·Andrew MolyneuxUNKNOWN International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group
Mar 15, 2003·Stroke; a Journal of Cerebral Circulation·Armin J GrauAndreas Ruf
Jun 15, 2006·Blood·Jean-Sébastien HulotPascale Gaussem
Jul 13, 2007·Clinical Pharmacology and Therapeutics·I RudbergE Molden
Sep 22, 2007·AJNR. American Journal of Neuroradiology·N K YamadaR G Dacey
Sep 29, 2007·Journal of Thrombosis and Haemostasis : JTH·J T BrandtK J Winters
Nov 9, 2007·AJNR. American Journal of Neuroradiology·S PrabhakaranD K Lopes
Sep 11, 2008·Pharmacogenomics·Tobias GeislerMatthias Schwab
Nov 21, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·D J PandyaO O Zaidat
Dec 26, 2008·Lancet·Jean-Philippe ColletGilles Montalescot
Apr 3, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Vasco DiasSevero Torres
May 8, 2009·Thrombosis Journal·Cosmo GodinoAntonio Colombo
Aug 27, 2009·JAMA : the Journal of the American Medical Association·Alan R ShuldinerPaul A Gurbel
Oct 9, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Miho KazuiAtsushi Kurihara
Jan 20, 2010·Circulation·Dirk SibbingAdnan Kastrati
May 12, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Yan HuangUNKNOWN Project Group for Demonstration Study of Syndrome Differentiation Protocol and Effect Evaluation of Acute Ischemic Stroke
Sep 14, 2010·European Heart Journal·Ankie M HarmszeVera H M Deneer
Sep 28, 2010·Neurosurgery·Hyun-Seung KangChang Wan Oh
Nov 30, 2010·Journal of Korean Neurosurgical Society·Dal-Sung RyuJin-Yang Joo
Jul 26, 2011·Yonsei Medical Journal·Jun-Beom LeeKyung-Yul Lee
Sep 6, 2011·Journal of Korean Neurosurgical Society·Gyoung-Jun RhoByung-Hee Lee
Mar 29, 2012·Neurointervention·Deok Hee LeeDae Chul Suh
Jan 1, 2013·AJNR. American Journal of Neuroradiology·C GohB Yan
Sep 28, 2013·Journal of the American Heart Association·Sirwan K L DarweeshBruno H Stricker
Apr 26, 2014·Circulation. Cardiovascular Genetics·Sharon CresciRichard G Bach
Citations
Jul 1, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Irina PiatkovMark McLean
Sep 17, 2016·Journal of Neurointerventional Surgery·Huijian GeYouxiang Li
Jun 20, 2018·Clinical Pharmacology and Therapeutics·Ljiljana Rakicevic, Aleksandra Nestorovic
Dec 16, 2019·Neurosurgery·Alejandro Enriquez-Marulanda, Ajith J Thomas
Aug 1, 2019·Shock·Maria CohenYoram Vodovotz
Feb 6, 2021·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Axel RosengartChristoph J Griessenauer
Feb 22, 2021·Translational Stroke Research·Pious D PatelRohan V Chitale
May 23, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Subhashaan SreedharanBernard Yan
Mar 18, 2021·Scientific Reports·Yan-Jiao LiYan-Qing Song
Aug 31, 2021·Current Reviews in Clinical and Experimental Pharmacology·Ehab S El Desoky