Association Between CYP3A4 and CYP3A5 Genotypes and Cyclosporine's Blood Levels and Doses among Jordanian Kidney Transplanted Patients

Current Drug Metabolism
Sahar El-ShairMalek Zihlif

Abstract

Cyclosporine is used as an immunosuppressive agent in kidney transplantation. It has a narrow therapeutic window. Cyclosporine is predominantly metabolized by CYP3A4 and CYP3A5. The most common Single Nucleotide Polymorphisms (SNPs) affecting cyclosporine metabolism (CYP3A4*1B, CYP3A4*1G, CYP3A4*22 and CYP3A5*3) were investigated among Jordanian kidney transplanted patients to find out the genotypes and allele frequencies of these SNPs. Additionally, this study investigated whether genotypes of CYP3A4 and CYP3A5 affect C2 blood levels, dosing of cyclosporine and the prevalence of acute rejection. Blood samples of 109 adult patients taking cyclosporine as their primary immunosuppressant for kidney transplantation were collected from the Prince Hamzah Hospital, Amman, Jordan. Patients' first C2 blood levels and their first two given doses were collected. Patients were genotyped for the four SNPs using Polymerase Chain Reaction- restriction Fragment Length Polymorphism (PCR-RFLP) assay method. Allele frequencies among Jordanian patients for CYP3A4*1B, CYP3A4*1G, CYP3A4*22 and CYP3A5*3 were 0.037, 0.399, 0.037 and 0.271, respectively. There was a significant association between CYP3A4*22 and mean difference in the second and first ...Continue Reading

References

Jun 1, 1988·British Journal of Clinical Pharmacology·A G RenwickC F George
May 21, 1999·Biochemical and Biophysical Research Communications·A WestlindM Ingelman-Sundberg
Mar 5, 2002·Pharmacogenetics·Jatinder K LambaErin G Schuetz
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Dario CattaneoGiuseppe Remuzzi
Sep 29, 2004·Biochemical Pharmacology·Yang DaiKenneth E Thummel
May 11, 2005·BMC Medical Genetics·Adam A GarsaSharon Marsh
Aug 27, 2005·The New England Journal of Medicine·Julie R Ingelfinger, Robert S Schwartz
May 1, 2007·Pharmacogenomics·Markus SchirmerLeszek Wojnowski
Jul 13, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Y F HuH H Zhou
Jan 24, 2008·Journal of Clinical Pharmacy and Therapeutics·S Y ParkK O Han
Dec 9, 2009·Clinical and Experimental Immunology·G ZazaF P Schena
Mar 26, 2011·Expert Opinion on Drug Metabolism & Toxicology·Nicolas Picard, Pierre Marquet
Feb 24, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nicholas Ware
Mar 14, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Abdulkareem AlbekairyJanet Karlix
Aug 8, 2013·Pharmacogenetics and Genomics·Julia M BarbarinoRuss B Altman
Jan 2, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jin Sol LeeHyoung Doo Shin
Oct 29, 2012·Journal of Personalized Medicine·Danxin Wang, Wolfgang Sadee
Jun 14, 2014·Clinical Pharmacology and Therapeutics·A N Werk, I Cascorbi
Aug 28, 2014·Current Opinion in Nephrology and Hypertension·Kelly Birdwell

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Citations

Jun 1, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Aline MilaneAntoine Barbari
Jul 27, 2021·Frontiers in Genetics·Tessa A M MulderRon H N van Schaik
Sep 14, 2021·Frontiers in Pharmacology·Jin-Woo ParkJi-Young Park

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