Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder

Journal of Autism and Developmental Disorders
Yan LiYawen Liu

Abstract

Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD.

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Citations

Apr 30, 2020·Journal of Autism and Developmental Disorders·Amirhosein Meisami
Jul 2, 2020·Journal of Autism and Developmental Disorders·Yan LiYawen Liu
Dec 31, 2020·International Journal of Environmental Research and Public Health·Dominique H ComoSharon A Cermak

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