Association between depression and risk of atrial fibrillation and stroke in patients with psoriasis: a Danish nationwide cohort study

The British Journal of Dermatology
A EgebergPeter Riis Hansen

Abstract

Psoriasis and depression are associated with atrial fibrillation (AF) and stroke, but the influence of depression on the risk of stroke and AF in patients with psoriasis has not been examined. We investigated the impact of depression on the risk of stroke and AF in patients with psoriasis in a nationwide cohort. Data on all Danish citizens aged ≥ 18 years between 1 January 1997 and 31 December 2011 (n = 5 251 888) were linked at the individual level in nationwide registers. Incidence rates (IRs) per 1000 person-years were calculated, and hazard ratios (HRs) adjusted for age, sex, concomitant medication and comorbidity were estimated by multivariate Cox regression models. There were 56,496 and 11,357 incident cases of mild and severe psoriasis, respectively. Incident depression occurred among 12,788 cases with mild and 3261 cases with severe psoriasis. IRs per 1000 patient-years of AF were 3·21, 5·02, 8·41, 5·39 and 7·41; and IRs of stroke were 2·62, 3·09, 6·71, 3·62 and 9·03 for the reference population, mild psoriasis without depression, mild psoriasis with depression, severe psoriasis without depression and severe psoriasis with depression, respectively. The respective HRs for new-onset AF were 1·14 [95% confidence interval (...Continue Reading

References

Jul 22, 1998·Archives of General Psychiatry·D L MusselmanC B Nemeroff
Mar 4, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S LanquillonH Vedder
Jun 1, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·B E Leonard
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Søren BakDavid Gaist
Oct 31, 2002·Human Psychopharmacology·Michael Maes
Nov 19, 2003·Circulation·Ronnier J AvilesMina K Chung
Jun 25, 2005·European Heart Journal·Mads D M Engelmann, Jesper Hastrup Svendsen
Oct 13, 2006·JAMA : the Journal of the American Medical Association·Joel M GelfandAndrea B Troxel
Dec 2, 2006·Stroke; a Journal of Cerebral Circulation·Francisco Javier Carod-Artal
Jan 9, 2007·The American Journal of Medicine·Lars FrostLeif Spange Mortensen
May 5, 2007·Neuroepidemiology·Lars-Henrik KrarupThomas Truelsen
Nov 6, 2007·Journal of Psychosomatic Research·Helmut W Lange, Christoph Herrmann-Lingen
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Dec 18, 2009·Biological Psychiatry·Yekta DowlatiKrista L Lanctôt
Feb 22, 2011·Biological Psychiatry·Adrie SeldenrijkBrenda W J H Penninx
Aug 16, 2011·European Heart Journal·Ole AhlehoffPeter Riis Hansen
Sep 22, 2011·JAMA : the Journal of the American Medical Association·An PanFrank B Hu
Mar 10, 2012·BMJ : British Medical Journal·Jesper LindhardsenPeter Riis Hansen
Sep 28, 2012·The Journal of Investigative Dermatology·Rosa ParisiUNKNOWN Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team
Oct 4, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·P L DominguezA A Qureshi
Mar 16, 2013·Diabetes Care·Usman KhalidOle Ahlehoff
Oct 11, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Søren Lund KristensenPeter Riis Hansen
Oct 30, 2013·Archives of Dermatological Research·April W ArmstrongEhrin J Armstrong
Nov 29, 2013·The Journal of Investigative Dermatology·Emmilia A DowlatshahiTamar Nijsten
May 20, 2014·Neuroscience Bulletin·Qiu-Qin Han, Jin Yu
May 31, 2014·Stroke; a Journal of Cerebral Circulation·Graeme J Hankey
Jun 25, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Wendy Thomson

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Citations

Sep 9, 2015·The British Journal of Dermatology·M Weichenthal
Jul 28, 2016·Indian Journal of Dermatology, Venereology and Leprology·Patompong UngprasertWonngarm Kittanamongkolchai
Mar 7, 2018·Reviews in the Neurosciences·Man AmanatNima Rezaei
Jun 6, 2019·Anais Brasileiros De Dermatologia·Marcelo ArnoneTatiana Jerez Jaime
Feb 27, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Monika GawałkoJędrzej Kosiuk

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