Association between detectable SARS-COV-2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019

Journal of Medical Virology
Weiyin LinLinghua Li

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was found in the intestines and feces, but its clinical significance is not completely clear. We aim to characterize the longitudinal test results of SARS-CoV-2 RNA in anal swabs and to explore the association with disease severity. We included laboratory-confirmed coronavirus disease 2019 (COVID-19) patients, who were hospitalized in Guangzhou Eighth People's Hospital and excluded those who had not received anal swabs for SARS-COV-2 RNA testing. Epidemiological, clinical, and laboratory data were obtained. Throat swabs and anal swabs were collected periodically for SARS-COV-2 RNA detection. Two hundred and seventeen eligible patients (median aged 50 years, 50.2% were females) were analyzed. 21.2% (46/217) of the patients were detected with SARS-CoV-2 RNA in anal swabs. The duration of viral RNA was longer, but the viral load was lower in anal swabs than throat swabs in the early stage of the disease. During a median follow-up of 20 days, 30 (13.8%) patients were admitted to the intensive care unit (ICU) for high-flow nasal cannula or higher-level oxygen support measures to correct hypoxemia. Detectable viral RNA in anal swabs (adjusted hazard ratio [aHR], 2.50; 9...Continue Reading

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Citations

Sep 3, 2020·Critical Care : the Official Journal of the Critical Care Forum·Amir ShlomaiElla H Sklan
Oct 29, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Thi Loi DaoPhilippe Gautret
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Mar 2, 2021·World Journal of Gastroenterology : WJG·Tarun SahuHenu Kumar Verma
Aug 2, 2021·Digestive Diseases and Sciences·Giulia ConcasMaria Antonietta Marcialis

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS

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