Association between diabetes mellitus and gastroesophageal reflux disease: A meta-analysis

World Journal of Gastroenterology : WJG
Xiao-Meng SunLin Lin

Abstract

To investigate whether there is a link between diabetes mellitus (DM) and gastroesophageal reflux disease (GERD). We conducted a systematic search of PubMed and Web of Science databases, from their respective inceptions until December 31, 2013, for articles evaluating the relationship between DM and GERD. Studies were selected for analysis based on certain inclusion and exclusion criteria. Data were extracted from each study on the basis of predefined items. A meta-analysis was performed to compare the odds ratio (OR) in DM between individuals with and without GERD using a fixed effect or random effect model, depending on the absence or presence of significant heterogeneity. Subgroup analyses were used to identify sources of heterogeneity. Publication bias was assessed by Begg's test. To evaluate the results, we also performed a sensitivity analysis. When the electronic database and hand searches were combined, a total of nine eligible articles involving 9067 cases and 81 968 controls were included in our meta-analysis. Based on the random-effects model, these studies identified a significant association between DM and the risk of GERD (overall OR = 1.61; 95%CI: 1.36-1.91; P = 0.003). Subgroup analyses indicated that this resul...Continue Reading

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Citations

Oct 28, 2016·Annals of the New York Academy of Sciences·Jingbo Zhao, Hans Gregersen
Sep 13, 2017·Middle East Journal of Digestive Diseases·Zohre KhodamoradiReza Malekzadeh
Dec 18, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Suna Selbuz, Ayşe Derya Buluş
May 14, 2019·Dose-response : a Publication of International Hormesis Society·Wen-Ling LinChia-Hung Kao
Jun 27, 2020·International Journal of Environmental Research and Public Health·Chun-Gu ChengChun-An Cheng
Jul 2, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Michael Wakeman, David T Archer
Nov 22, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Amandeep SinghNaim Alkhouri
Dec 16, 2019·Current Problems in Surgery·Laura FloresDmitry Oleynikov

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