Association between diverticular disease requiring surgical intervention and mortality in the postlung transplant population - a retrospective cohort study

Transplant International : Official Journal of the European Society for Organ Transplantation
Laneshia K TagueErin M Lowery

Abstract

Lung Transplant recipients are at increased risk of complicated diverticular disease. We aim to assess the rate of diverticular surgery in a postlung transplantation population and identify risk factors for surgery. We performed a retrospective cohort study of lung transplant recipients from 2007 to 2011. Demographic variables were evaluated with the Mann-Whitney U and chi-squared tests. Cox regression was performed to evaluate 1- and 2-year landmark survival, assess predictor variables of diverticular surgery and evaluate impact of surgery on CLAD development. Of 17 of 158 patients (10.7%) underwent diverticular-related surgery. Surgical patients had significantly worse survival than nonsurgical patients at 1 year [aHR 2.93 (1.05-8.21), P = 0.041] and 2 year [aHR 4.17 (1.26-13.84), P = 0.020] landmark analyses. Transplant indication of alpha-1 antitrypsin disease and cystic fibrosis were significantly associated with the need for diverticular surgery. Emergent surgery was associated with poorer survival [aHR 5.12(1.00-26.27), P = 0.050]. Lung transplant patients requiring surgery for complicated diverticular disease have significantly poorer survival than those who do not require surgery. Surgery was more common in patients tr...Continue Reading

References

Jul 1, 1991·Archives of Surgery·E S TyauD L Nahrwold
Oct 1, 1984·Annals of Surgery·G V Rodkey, C E Welch
Sep 1, 1996·The Annals of Thoracic Surgery·T M BeaverF L Grover
Aug 10, 2000·Current Problems in Surgery·T M Young-FadokB G Wolff
Feb 26, 2004·The European Respiratory Journal·R M Kotloff, V N Ahya
Jul 21, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Raffi A QasabianAnne Keogh
Aug 3, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·H N Aydin, F H Remzi
Dec 27, 2005·Journal of the American College of Surgeons·Hilary J GoldbergKelli M Bullard
Jun 3, 2006·Diseases of the Colon and Rectum·Janice RaffertyUNKNOWN Standards Committee of American Society of Colon and Rectal Surgeons
Aug 4, 2006·Journal of Clinical Gastroenterology·Sidney T Bogardus
Sep 25, 2007·Transplantation Proceedings·C BravoUNKNOWN MITOS Study Group
Nov 11, 2008·Gastroenterology·Lisa L StrateEdward L Giovannucci
Nov 14, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Chao-Yang ChenCheng-Wen Hsiao
Jan 20, 2009·World Journal of Gastroenterology : WJG·Antje JansenChristoph Elsing
May 7, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Subroto PaulDavid B Lautz
Aug 10, 2010·Current Gastroenterology Reports·Jason Hemming, Martin Floch
Jul 19, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Rajeev SwarupAlan D Betensley
Oct 20, 2011·The American Journal of Gastroenterology·Fredrik HjernNiclas Håkansson
Nov 9, 2011·Gastroenterology·Anne F PeeryRobert S Sandler
May 4, 2012·The Journal of Thoracic and Cardiovascular Surgery·Hagen BombergHans-Joachim Schäfers
May 9, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A ReshefF H Remzi
Jul 11, 2012·The American Journal of Gastroenterology·Lisa L StrateBrennan M R Spiegel
Apr 1, 2014·The Annals of Thoracic Surgery·Roberto LorussoSandro Gelsomino
Apr 9, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Pia BredahlMartin Iversen
Jun 11, 2014·The Journal of Surgical Research·Eric S LarsonJames Yoo
Aug 17, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·J E OorÇ Ünlü
Sep 23, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Roger D YusenUNKNOWN International Society for Heart and Lung Transplantation
Feb 7, 2015·Inflammatory Bowel Diseases·Shay MatalonIris Dotan
May 31, 2016·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Andreas BrandlRobert Öllinger
Aug 16, 2016·Transplantation·James H Tabibian, Saad S Kenderian
Aug 25, 2016·International Journal of Chronic Obstructive Pulmonary Disease·Hanan A TanashEeva Piitulainen
Sep 2, 2016·World Journal of Emergency Surgery : WJES·Nicola de'AngelisDaniel Azoulay
Oct 25, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Roger D YusenUNKNOWN International Society for Heart and Lung Transplantation
Oct 13, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Andreas GleissGeorg Heinze
Dec 8, 2017·Yonsei Medical Journal·Mi Young Yoon, Sang Sun Yoon
Dec 10, 2017·Archives of Medical Research·Tadasu IizumiGuillermo I Perez Perez
Apr 24, 2018·BioMed Research International·Ravichandra VemuriRajaraman Eri
May 31, 2018·Interactive Cardiovascular and Thoracic Surgery·Pascale SulserIlhan Inci

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Citations

Jun 26, 2020·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Michael T OlsonRoss M Bremner

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