Association Between Duration of Delayed Graft Function, Acute Rejection, and Allograft Outcome After Deceased Donor Kidney Transplantation

Transplantation
Wai H LimGermaine Wong

Abstract

Prolonged duration of delayed graft function (DGF) may be associated with adverse allograft outcomes, but the association between threshold duration of DGF, acute rejection and long-term allograft loss remains undefined. We aimed to determine the impact of DGF duration on allograft outcomes and to assess whether this association was mediated by acute rejection. Using data from the Australian and New Zealand Dialysis and Transplant Registry, Cox proportional modeling was used to determine the association between quartiles of DGF duration, acute rejection at 6 months and death-censored graft loss (DCGL). Mediation analysis was conducted to determine whether acute rejection was a causal intermediate between DGF and DCGL. Of 7668 deceased donor kidney transplants between 1997 and 2014, 1497 (19.5%) recipients experienced DGF requiring dialysis. The median (interquartile range) duration of DGF was 7 (9) days, with 25% requiring dialysis for 14 days or longer. Among recipients who had experienced a DGF duration of 1 to 4 days, the adjusted hazard ratio for duration of 5 to 7, 8 to 13, and 14 days or longer were 1.13 (95% confidence interval [CI], 0.83-1.55; P = 0.43), 1.44 (95% CI, 1.08-1.91; P = 0.013), and 1.99 (95% CI, 1.50-2.65; ...Continue Reading

References

Jun 12, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ricard SolaAntonio Osuna
Nov 13, 2008·Prevention Science : the Official Journal of the Society for Prevention Research·Amanda J Fairchild, David P MacKinnon
Dec 24, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sri G YarlagaddaChirag R Parikh
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W D IrishD C Brennan
Sep 21, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A SiedleckiD C Brennan
Sep 24, 2013·Transplantation·Dermot H MallonGavin J Pettigrew
Dec 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudio Ponticelli
Jan 31, 2015·Kidney International·Claudio E Ponticelli
Mar 19, 2015·Kidney International·Dominic M SummersJ Andrew Bradley
Dec 19, 2015·PloS One·Tainá Veras de Sandes-FreitasJosé Osmar Medina-Pestana
Aug 9, 2016·Transplantation·Isaac E HallChirag R Parikh

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Citations

Jan 28, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Awad ShamaliChris Callaghan
Dec 10, 2019·Current Opinion in Organ Transplantation·Umberto MaggiorePaolo Cravedi
Jun 4, 2020·Biomolecules·Daniela CoronaMassimiliano Veroux
Oct 1, 2020·Pediatric Transplantation·Luiza do Nascimento Ghizoni PereiraPaulo Cesar Koch-Nogueira
Sep 17, 2019·World Journal of Transplantation·Justin W BlazelSandesh Parajuli
Dec 20, 2019·Journal of the American Society of Nephrology : JASN·Germaine WongJonathan C Craig
Jul 16, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Josep M Grinyó
Mar 21, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Tainá Veras de Sandes-FreitasUNKNOWN DGF-Brazil Study Group†
Mar 24, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Benedict L PhillipsChris J Callaghan
May 31, 2019·Current Opinion in Organ Transplantation·Smriti JuriasinganiAlp Sener
Oct 20, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eva SchrezenmeierLukas J Lehner

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