Association between duration of symptoms and severity of disease at first presentation to paediatric rheumatology: results from the Childhood Arthritis Prospective Study.

Rheumatology
Navid AdibWendy Thomson

Abstract

To study the association between disease severity at first presentation to paediatric rheumatology (PRh) and length of time since symptom onset in children recruited to the Childhood Arthritis Prospective Study. Children <or=16 yrs with inflammatory arthritis persisting >or=2 weeks were recruited from five UK hospitals. Data including demographics, disease features, Childhood Health Assessment Questionnaire (CHAQ), physician and parent global assessment and blood tests were collected at the first appointment with PRh (baseline). The association between symptom duration (defined as time from first reported symptom onset to presentation at PRh) and baseline disease characteristics was evaluated using non-parametric descriptive statistics and multivariable logistic regression analyses. Five hundred and seven children (65% female) were included: median age at onset was 6.8 yrs. Two hundred and thirty-three had oligoarthritis, 68 had RF-negative polyarthritis, 27 had systemic onset arthritis and 29 had arthritis that was not JIA. The median symptom duration was 4.6 months. Median symptom duration was shortest for children presenting with systemic arthritis (1.6 months) and longest for those with PsA (8.6 months). Children with a lon...Continue Reading

References

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Citations

Dec 22, 2012·Annals of the Rheumatic Diseases·Flora McErlaneUNKNOWN Childhood Arthritis Prospective Study (CAPS)
Aug 14, 2009·Annals of the Rheumatic Diseases·Anne HinksWendy Thomson
Apr 4, 2013·Pediatric Rheumatology Online Journal·Anne HinksRachelle P Donn
May 14, 2010·Genes and Immunity·A HinksW Thomson
Mar 12, 2016·International Journal of Inflammation·Mohammad H Al-HemairiMohammed A Muzaffer
May 9, 2012·Pediatric Clinics of North America·Jay Mehta
Oct 27, 2009·Best Practice & Research. Clinical Rheumatology·Gail Faller, Roger C Allen
Sep 4, 2015·The Journal of Pain : Official Journal of the American Pain Society·C Jeffrey JacobsonEsi Morgan DeWitt
Mar 24, 2016·Zeitschrift für Rheumatologie·A HospachF Weller-Heinemann
Apr 14, 2018·Modern Rheumatology·Toshihide MimuraTakayuki Sumida
Nov 28, 2017·Archives of Disease in Childhood·Amir RashidWendy Thomson
Aug 30, 2017·Clinical Reviews in Allergy & Immunology·Marco CattaliniRolando Cimaz
Jul 18, 2019·Arthritis & Rheumatology·Laura E SchanbergYukiko Kimura
Feb 12, 2020·Rheumatology·Michelle BatthishUNKNOWN Canadian Alliance of Pediatric Rheumatology Investigators
Mar 16, 2019·Arthritis Care & Research·Stephanie J W Shoop-WorrallJanet E McDonagh
May 18, 2017·Pediatric Rheumatology Online Journal·Khulood Khawaja, Mustafa Al-Maini
Sep 16, 2017·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Rebecca Rachael LeeLis Cordingley
Sep 20, 2011·European Journal of Ophthalmology·Amany Abdel-Fattah El-Shazly, Ahmed Abdullah Mohamed
Aug 16, 2019·BMC Health Services Research·Claire E H BarberNatalie J Shiff
Sep 6, 2020·Annals of the Rheumatic Diseases·Rodrigo CánovasMichael Inouye
May 24, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·Caroline FreychetAurélie Chausset
Sep 25, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Semanur OzdelMehmet Bulbul
Apr 15, 2020·Arthritis Care & Research·Stephanie J W Shoop-WorrallSuzanne M M Verstappen

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